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Kwon, Koh, Kim, Han, Lee, and Shim: Two cases of Endobronchial Neurilemmoma and Review of the Literature in Korea
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2007; 62(2): 129-133.

Published online: 28 February 2007

DOI: https://doi.org/10.4046/trd.2007.62.2.129

Two cases of Endobronchial Neurilemmoma and Review of the Literature in Korea

Yong Soo Kwon, M.D., Won-Jung Koh, M.D., Hojoong Kim, M.D., Joungho Han, M.D.1, Kyung Soo Lee, M.D.2, Young Mok Shim, M.D.3

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

2Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

3Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Address for correspondence: Won-Jung Koh, MD. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gngnam-gu, Seoul 135-710, Korea. Telephone: (822) 3410-3429, Fax: (822) 3410-3849, wjkoh@smc.samsung.co.kr

Received 15 January 2007       Accepted 6 February 2007

Copyright © 2007 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Neurilemmomas are benign tumors that originate from Schwann cells. These tumors rarely occur in the trachea or bronchus. Although small peripheral lesions cause no symptoms, they usually cause dyspnea, cough, wheeze, and atelectasis. We encountered two cases of endobronchial neurilemmoma, and reviewed 10 cases previously reported in Korea in order to clarify the characteristics of this disease, and to determine the appropriate treatment. The median age of the 12 patients reviewed were 36.5 (range 16-75). Cough and dyspnea were the most common initial symptoms (40%), and two cases had no symptoms. Regarding the diagnostic methods, bronchoscopic biopsy was found to be inadequate for diagnosis in two cases. A review of the cases revealed the following teatments: bronchoscopic removal in two cases, surgery in six cases, and combined bronchoscopic removal and surgery in one case.

Keywords: Neurilemmoma, Bronchus, Bronchoscopy

Figures and Tables

Figure 1
(A) Enhanced chest CT scan (5.0 mm section thickness) obtained at the level of the main bronchi shows homogeneous endobronchial nodule (arrows) obliterating right upper lobar bronchus. (B) Bronchoscopic finding showes a round hypervascular mass with smooth surface in the right main bronchus. (C) Photomicrography of endobronchial neurilemmoma consists of elongated bipolar cells disposed in fascicles (H&E, ×100). (D) Tumor cells are uniformly reactive for S-100 protein (ABC method, ×100).
trd-62-129-g001
Figure 2
(A, B) Mediastinal- (A) and lung-window (B) images of unenhanced CT scan (5.0-mm section thickness) obtained at the ventricular level shows a homogeneous nodule in left lower lobe. (C) Bronchoscopic finding showed a obstructing mass with hypervascular surface in the posterobasal segmental bronchus of the left lower lobe. (D) Photomicrography of endobronchial neurilemmoma shows prominent rows of cells with nuclear palisading (H&E, ×100). (E) Tumor cells are uniformly reactive for S-100 protein (ABC method, ×200).
trd-62-129-g002
Table 1
Clinical, radiologic, diagnostic methods and treatment of patients with endobronchial neurilemmoma reported in Korea
trd-62-129-i001

M: male, F: female, LUL: left upper lobe, RLL: right lower lobe, RML: right middle lobe, RUL: right upper lobe, N/A: not available.

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