Journal List > Tuberc Respir Dis > v.61(1) > 1001047

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No, Hur, Lee, Lee, Lee, Kim, Choi, Yum, Choi, Kim, and Lee: A Case of Alpha-Fetoprotein Producing Adenocarcinoma of the Lung
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(1): 70-73.

Published online: 31 July 2006

DOI: https://doi.org/10.4046/trd.2006.61.1.70

A Case of Alpha-Fetoprotein Producing Adenocarcinoma of the Lung

Eun-Ji No, M.D., Jin-Won Hur, M.D., Sung Soon Lee, M.D., Young Min Lee, M.D., Hyuk Pyo Lee, M.D., Joo In Kim, M.D., Soo Jeon Choi, M.D., Ho-Kee Yum, M.D., Suk-Jin Choi, M.D.1, Chan-Hwan Kim, M.D.2, Hyun-Kyung Lee, M.D.

Department of Internal Medicine, Pusan Paik Hospital, Inje University, Korea.

1Department of Radiology, Pusan Paik Hospital, Inje University, Korea.

2Department of Pathology, Pusan Paik Hospital, Inje University, Korea.

Address for correspondence: Hyun-Kyung Lee, M.D. Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine, 633-165, Gae-gum-2-dong, Jin-Gu, Busan, 614-735, Korea. Phone: 82-51-890-6270 Fax: 82-51-892-0273, drpulmo@inje.ac.kr

Received 24 April 2006       Accepted 14 June 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Alpha-fetoprotein(AFP) is a plasma protein produced in the fetal liver, yolk sac and gastrointestinal tract. The plasma level of AFP decreases markedly 1 year after birth. The AFP level is usually increased in hepatocellular carcinoma and yolk sac tumor but is rare in a primary lung cancer. We report a case of primary adenocarcinoma of lung producing high levels of AFP.

Keywords: Alpha-fetoprotein, Lung cancer, Adenocarcinoma

Figures and Tables

Figure 1
Lobulated huge mass is in the right upper lobe. Air-fluid level is in the infected bulla.
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Figure 2
The CT scan reveals lobulated mass in posterior segment of right upper lobe. Infected bullae is in superior segment of the right lower lobe.
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Figure 3
Poorly differentiated cluster showing sinusoidal pattern, gland formation (H & E, × 200)
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Figure 4
Cytoplasm of tumor cell in the lung shows positive cytokeratin staining (H & E, × 200).
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Figure 5
Cytoplasm of tumor cell in the lung shows positive CEA staining (H & E, × 200).
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Figure 6
Tumor cell in the lung cut shows positive staining for AFP (H & E, × 200).
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