Journal List > Tuberc Respir Dis > v.61(6) > 1001044

TOOLS
Baek, Ryu, Hong, Yoo, Yu, Son, Kim, Kang, Kim, Lee, Cho, Yoon, Kwak, Lee, and Kim: Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(6): 591-594.

Published online: 30 December 2006

DOI: https://doi.org/10.4046/trd.2006.61.6.591

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient

Yong-Soo Baek, M.D.1, Jeong-Seon Ryu, M.D.1, Seong-Bin Hong, M.D.1, Sung-Soo Yoo, M.D.1, Hyung-Kwon Yu, M.D.1, Dong-Wook Son, M.D.1, Lucia Kim, M.D.2, Hye-Sun Kang, M.D.1, Beom-Joon Kim, M.D.1, Kyung-Hee Lee, M.D.3, Jae-Hwa Cho, M.D.1, Young-Han Yoon, M.D.4, Seung-Min Kwak, M.D.1, Hong-Lyeol Lee, M.D.1, Kwang-Ho Kim, M.D.4

1Department of Internal Medicine, College of Medicine, Inha University, Incheon, South Korea.

2Department of Pathology, College of Medicine, Inha University, Incheon, South Korea.

3Department of Radiology, College of Medicine, Inha University, Incheon, South Korea.

4Department of Chest Surgery, College of Medicine, Inha University, Incheon, South Korea.

Address for correspondence: Jeong Seon Ryu, M.D. Associate Professor, Pulmonary Division, Dept. of Internal Medicine, Inha University Hospital 7-206, 3-Ga, Shinheung Dong, Jung Gu, Inchon, 400-103, Korea. Fax: 82-32-882-6578, Phone: 82-32-890-3738, jsryu@inha.ac.kr

Received 13 October 2006       Accepted 4 December 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

We report a case of pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following adjuvant chemotherapy. A 51-year-old woman with stage IIIA adenocarcinoma received left lower lobe lobectomy in July, 2006. And then combination chemotherapy with paclitaxel and cisplatin was given to the patient. In five days after completion of second cycle of the chemotherapy, she visited emergency room because of general weakness and seizure. Her brain MRI was shown to be no evidence of brain metastasis. Serum sodium, urine and plasma osmolarities were 117mEq/L, 589 and 244mOsm/kg, respectively. She was improved with fluid restriction. Although occurrence of SIADH following chemotherapy is rare, physician should give an attention the potential for development of SIADH in the course of chemotherapyin non-small cell lung cancer patient.

Keywords: Syndrome of inappropriate secretion of antidiuretic hormone, Chemotherapy, Non-small cell lung cancer, Seizure

Figures and Tables

Figure 1
On chest CT scan, 1.8 cm sized solitary pulmonary nodule was noted in lateral basal segment of left lower lobe at the time of diagnosis (left). No disease progression was noted on follow-up chest CT after two cycles of adjuvant chemotherapy (right).
trd-61-591-g001
Figure 2
Microscopic finding of adenocarcinoma of lung (H&E staining, ×200). The tumor was predominantly composed of malignant glandular cells forming irregular shaped acini and some papillae.
trd-61-591-g002
Figure 3
No evidence of brain metastasis was revealed on brain MRI after seizure.
trd-61-591-g003
Table 1
Laboratory data before and four days after chemotherapy
trd-61-591-i001

References

1. List AF, Hainsworth JD, Davis BW, Hande KR, Greco FA, Johnson DH. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in small-cell lung cancer. J Clin Oncol. 1986. 4:1191–1198.
2. Sorensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med. 1995. 238:97–110.
3. Tho LM, Ferry DR. Is the paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in lung cancer always attributable to the small cell variety? Postgrad Med J. 2005. 81:e17.
4. Monsieur I, Meysman M, Noppen M, de Greve J, Delhove O, Velckeniers B, et al. Non-small-cell lung cancer with multiple paraneoplastic syndromes. Eur Respir J. 1995. 8:1231–1234.
5. Karthik S, Roop R, Mediratta NK. Adenocarcinoma of lung presenting with dysgeusia. Thorax. 2004. 59:84.
6. Nakazato Y, Imai K, Abe T, Tamura N, Shimazu K. Unpleasant sweet taste: a symptom of SIADH caused by lung cancer. J Neurol Neurosurg Psychiatry. 2006. 77:405–406.
7. Kagawa K, Fujitaka K, Isobe T, Yamasaki M, Miyazaki M, Oguri T, et al. Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion. Intern Med. 2001. 40:1020–1023.
8. Ishii K, Aoki Y, Sasaki M, Tanaka K. Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin chemotherapy. Gynecol Oncol. 2002. 87:150–151.
9. Otsuka F, Hayashi Y, Ogura T, Hayakawa N, Ikeda S, Makino H, et al. Syndrome of inappropriate secretion of antidiuretic hormone following intra-thoracic cisplatin. Intern Med. 1996. 35:290–294.
10. Littlewood TJ, Smith AP. Syndrome of inappropriate antidiuretic hormone secretion due to treatment of lung cancer with cisplatin. Thorax. 1984. 39:636–637.
11. Fukabori T, Nakamura T, Kida T, Fujita Y, Goto T, Hiramori N, et al. Syndrome of inappropriate antidiuretic hormone secretion following cisplatinum and vindesine administration in a patient with squamous cell carcinoma of the lung. Gan To Kagaku Ryoho. 1991. 18:1213–1216.
12. Langer-Nitsche C, Luck HJ, Heilmann M. Severe syndrome of inappropriate antidiuretic hormone secretion with docetaxel treatment in metastatic breast cancer. Acta Oncol. 2000. 39:1001.
13. Bjornson DC, Stephenson SR. Cisplatin-induced massive renal tubular failure with wastage of serum electrolytes. Clin Pharm. 1983. 2:80–83.
14. Hutchison FN, Perez EA, Gandara DR, Lawrence HJ, Kaysen GA. Renal salt wasting in patients treated with cisplatin. Ann Intern Med. 1988. 108:21–25.
15. Cao L, Joshi P, Sumoza D. Renal salt-wasting syndrome in a patient with cisplatin-induced hyponatremia: case report. Am J Clin Oncol. 2002. 25:344–346.
16. Levin L, Sealy R, Barron J. Syndrome of inappropriate antidiuretic hormone secretion following disdichlorodiammineplatinum II in a patient with malignant thymoma. Cancer. 1982. 50:2279–2282.
TOOLS
Similar articles