Journal List > Tuberc Respir Dis > v.61(6) > 1001041

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Jung, Byun, Chung, Park, Kang, Kim, Shin, Kim, Chang, Kim, and Kim: A Case of Pulmonary Metastasis of a Dermatofibrosarcoma Protuberans
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(6): 573-577.

Published online: 30 December 2006

DOI: https://doi.org/10.4046/trd.2006.61.6.573

A Case of Pulmonary Metastasis of a Dermatofibrosarcoma Protuberans

Se Jin Jung, M.D.1, Min Kwang Byun, M.D.1, Woo Young Chung, M.D.1, Moo Suk Park, M.D.1, 2, Shin Myung Kang, M.D.1, 2, Hae Ryoung Kim, M.D.3, Dong Hwan Shin, M.D.3, Se Kyu Kim, M.D.1, 2, Joon Chang, M.D.1, 2, Sung Kyu Kim, M.D.1, 2, Young Sam Kim, M.D.1, 2

1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.

3Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Address for correspondence: Young Sam Kim, M.D. Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, seodaemun-Ku, Seoul 120-752, South Korea. Phone: 82-2-2228-1965, Fax: 82-2-393-6884, ysamkim@yumc.yonsei.ac.kr

Received 7 August 2006       Accepted 11 October 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Dermatofibrosarcoma protuberans (DFPS) is a locally aggressive skin tumor with a very low incidence in the general population. This tumor has a remarkable tendency to recur, However, a metastasis is rare. We report a case of DFPS with a pulmonary metastasis in 28-year-old man. The pulmonary metastasis developed 5 years after a complete resection of the primary skin tumor. We reviewed the clinical manifestations and treatment of DFPS, and highlight the need for a long-term follow-up examination for metastases after a wide excision of these lesions.

Keywords: Dermatofibrosarcoma protuberans, Pulmonary metastasis

Figures and Tables

Figure 1
A) Low-power magnification of the right flank mass shows a solid cellular tumor with infiltrative borders and arranged in short fascicles (Original magnification ×40; Hematoxylin-eosin). B) The tumor cells show plump spindle-shaped nuclei and indistinct cytoplasmic borders (Original magnification ×200; Hematoxylin-eosin).
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Figure 2
A) Chest PA shows about 4 × 5 cm sized lobulated well-defined mass at left lower lobe. B) Chest CT shows a 4.4cm × 2.6cm sized mass at the anterior basal segment of left lower lobe.
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Figure 3
Whole body Positron emission and computed tomography(PET-CT) scan shows mass lesion with FDG uptake with moderate degree at left lower lobe. It was compatible with metastasis of soft tissue sarcoma with intermediate grade.
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Figure 4
A) The metastasis tumor is relatively well-demarcated, and shows short fascicular arrangement similar to the pattern seen in the primary tumor (Original magnification ×100; Hematoxylin-eosin). B) Immunohistochemical stain shows strong cytoplasmic expression of CD34 in the tumor cells (Original magnification ×400).
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