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Lee, Yang, Jung, Lee, Sul, Kim, Kim, Choi, Na, and Son: Comparison of Thinprep (Liquid-Based Cytology) and Conventional Cytology : Abnormal Lesion on Bronchoscopy
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(6): 547-553.

Published online: 30 December 2006

DOI: https://doi.org/10.4046/trd.2006.61.6.547

Comparison of Thinprep (Liquid-Based Cytology) and Conventional Cytology : Abnormal Lesion on Bronchoscopy

Jung Ho Lee, M.D., Jung Kyung Yang, M.D., In Bum Jung, M.D., Jung Hea Lee, M.D.1, Hae Jung Sul, M.D.1, Yoon Mi Kim, M.D.1, Bum Kyeng Kim, M.D.1, Yue Jin Choi, M.D., Moon Joon Na, M.D., Ji Woong Son, M.D.

Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea.

1Department of Pathology, College of Medicine, Konyang University, Daejeon, Korea.

Address for correspondence: Ji Woong Son, M.D. Department of Internal Medicine College of Medicine, Konyang University, Hospital Gasoowon-Dong, Seo-Gu, Deajeon, 302-718, Korea. Phone number: (042) 600-8817, sk1609@hanmail.net

Received 26 October 2006       Accepted 7 December 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Liquid-based cytology is currently known as an effective method, and cervical cytology has been shown to be especially effective from of malignancy detection. In our study, the cytological detection rates of the Thinprep (Liquid-based cytology) and conventional cytology (bronchial washing & brushing) for endobronchial lesions were compared.

Methods

Between July 2005 and September 2005, the data from 30 patients with respiration symptom, who had shown abnormal lesion on bronchoscopy, were collected.

Results

The bronchoscopic biopsy group was consisted of 30 cytodiagnosis specimens, 24 of which were confirmed to be malignant. The others were tuberculosis (4), bronchiectasis and bronchopulmonary fistula (1 each). Of the 24 malignant case, cancer or atypical cells were detected in 19, 17 and 12 of the Thinprep, brushing cytology and washing cytology cases, respectively. None one of the methods detected cancer cells in the non-malignant specimens. Washing cytology has shown sensitivity, specificity, and positive and negative predictive values of 50, 100, 100 and 33.3% respectively. Brushing cytology has shown sensitivity, specificity, and positive and negative predictive values of 70.8, 100, 100 and 46.2%, respectively. Thinprep has shown sensitivity, specificity, and positive and negative predictive values of 79.2, 100, 100 and 54%, respectively.

Conclusions

Thinprep (liquid-based cytology) showed better sensitivity and negative predictive values for the evaluation of lung cancer than conventional cytology. However a large-scale study will be needed in the future.

Keywords: Thinprep, Conventional cytology, Bronchoscopy, Respiration cytology

Figures and Tables

Figure 1
Final diagnosis of the patient.
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Figure 2
Cellularity.
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Figure 3
Preservation.
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Figure 4
Background.
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Figure 5
Sensitivity.
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Figure 6
Negative predictability.
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Figure 7
Squamous cell carcinoma (a) Conventional preparation (b) Thinprep.(Papanicolaou stain, ×200)
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Figure 8
Sarcoma (a) Conventional preparation (b) ThinPrep (Papanicolaou stain, ×200)
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