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Choi, Chang, Lee, Sim, Ryu, Moon, Lee, Chun, and Chang: A Case of Triple Primary Cancers in Stomach, Larynx, and Lung
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(3): 279-284.

Published online: 30 September 2006

DOI: https://doi.org/10.4046/trd.2006.61.3.279

A Case of Triple Primary Cancers in Stomach, Larynx, and Lung

Ju Young Choi, M.D., Hye Jeong Chang, M.D., Min Jin Lee, M.D.1, Sung Sin Sim, M.D.2, Yon Ju Ryu, M.D., Jin Uk Moon, M.D., Jin Hwa Lee, M.D., Eun Mi Chun, M.D., Jung Hyun Chang, M.D.

Department of Internal Medicine, Collage of Medicine, Ewha Womans University, Seoul, Korea.

1Department of Pathology, Collage of Medicine, Ewha Womans University, Seoul, Korea.

2Department of Radiology, Collage of Medicine, Ewha Womans University, Seoul, Korea.

Address for correspondence: Eun Mi Chun, M.D. Department of Internal Medicine, Ewha Womans University, College of Medicine, Jongno 6-ga, Jongno-Ku, Seoul, Republic of Korea. Phone: 02-760-5120, Fax: 02-762-7756, cem@ewha.ac.kr

Received 10 March 2006       Accepted 7 August 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

A multiple primary malignant tumor is a disease mainly encountered in the of the older age groups. Attempts should be made to rule out a second primary malignant neoplasm in the elderly patients with unusual signs and symptoms. We encountered a case of a 67-year-old male with triple primary malignant tumors of the stomach, larynx, and lung. The patient had been treated with a subtotal gastrectomy for early gastric cancer in 1991 and a Laser laryngectomy for the laryngeal squamous cell carcinoma in 2003. In 2005, lung cancer was found with the biopsy revealing an adenosquamous carcinoma. Systemic chemotherapy was performed.

Keywords: Triple primary cancer, Lung cancer, Stomach cancer, Laryngeal cancer

Figures and Tables

Figure 1
(A) Chest PA view shows about 5.2 cm sized thin walled radiolucency (arrow) with ill demarcated osteolytic lesion (arrowhead) in left 6th posterior arc of rib. (B) Lung window of CT scan obtained at the level of azygos arch shows 4.7 cm sized thin walled cavitary mass (arrow) abutting posterior costal pleura in left lower lobe with adjacent focal ground glass attenuated lesion. (C) Mediastinal window of CT scan obtained at the same level of Fig. 2 show thin walled cavity with enhancing posterior costal pleural thickening. Irregular osteolytic lesion (arrow) in posterior arc of left 6th rib is observed. Less than 1 cm sized lymph node enlargement (arrowhead) is seen in left paratracheal area.
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Figure 2
Epiglottis. A(H & E, ×40) & 2B(H&E, ×200). Section disclosed portion shows moderately differentiated squamous cell carcimona.
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Figure 3
Stomach. A(H & E, × 100) & B(H&E, × 400). Microscopic examination shows ademocarcinoma.
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Figure 4
Lung(Adenosquamous carcinoma). A (H & E, ×200) Squamous cell carcinoma shows the proliferation of the squamous cell with atypical chage. B (PAS, ×400). Adenocarcinoma shows cytoplasmic mucin of glandular cell. PAS positive eosinophilic granular material(arrowhead) filled in the grandular cell is shown.
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