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Hwang, Kim, Jung, Park, Park, Kim, Kim, Yang, and Jeong: Phase II Study of Irinotecan Plus Cisplatin as First Line therapy in Extensive Small-Cell Lung Cancer
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(2): 143-149.

Published online: 31 August 2006

DOI: https://doi.org/10.4046/trd.2006.61.2.143

Phase II Study of Irinotecan Plus Cisplatin as First Line therapy in Extensive Small-Cell Lung Cancer

Ki Eun Hwang, M.D., So Young Kim, M.D., Jong Hoon Jung, M.D., Seong Hoon Park, M.D.1, Jung Hyun Park, M.D., Hwi Jung Kim, M.D., Hak Ryul Kim, M.D., Sei Hoon Yang, M.D., Eun Taik Jeong, M.D.

Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Korea.

1Department of Radiology, College of Medicine, Wonkwang University, Iksan, Korea.

Address for correspondence: Eun-Taik Jeong, M.D. Department of Internal Medicine, Wonkwang University Hospital, 344-2 Shinyong-dong, Iksan, Jeonbuk, 570-711, Korea. Phone: 063-850-1073, Fax: 063-855-2025, jetpul@wonkwang.ac.kr

Received 25 May 2006       Accepted 12 July 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Irinotecan (topoisomerase I inhibitor) is effective as a monotherapy against small-cell lung cancer(SCLC). Cisplatin is also an important drug against SCLC. A phase II study of irinotecan combined with cisplatin was carried out to evaluate the efficacy and toxicity of this combined regimen as a first line treatment in patients with extensive SCLC.

Methods

Thirty-nine patients with previously untreated extensive SCLC were enrolled in this study. Irinotecan 60mg/m2 was administered intravenously on days 1, 8 and 15, and in combination with cisplatin 60mg/m2 on day 1 and every 28 days thereafter. Four cycles of chemotherapy were given to the patients.

Results

The overall response rate was 77% with a complete response (CR) rate of 8%. The median survival time, 1- and 2-year survival rate were 14.8 months, 60.9% and 27.6%, respectively. The median progression free survival time, 6-and 12-month progression free survival rate were 8.4 months, 75% and 18.8%, respectively. The WHO grade 3 or more toxicity encountered were leukopenia (23%), diarrhea (26%). Two patients changed their chemotherapeutic regimen and one patient died from severe diarrhea.

Conclusion

The combination of irinotecan and cisplatin is effective as a first line therapy in extensive SCLC is effective , but has severe or fatal diarrhea as toxicity.

Keywords: Small-cell lung cancer, Irinotecan, Cisplatin

Figures and Tables

Figure 1
Kaplan-Meier survival curve
MST: median survival time
CI: confidence interval
trd-61-143-g001
Figure 2
Progression free survival curve
MPFS: median progression free survival time
CI: confidence interval
trd-61-143-g002
Table 1
Patients characteristics
trd-61-143-i001
Table 2
Toxic effects according to WHO grading
trd-61-143-i002

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