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Yang, Lee, Kim, and Kim: The Effect of a Proton-pump Inhibitor in Unexplained Chronic Cough Patients
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 61(2): 137-142.

Published online: 31 August 2006

DOI: https://doi.org/10.4046/trd.2006.61.2.137

The Effect of a Proton-pump Inhibitor in Unexplained Chronic Cough Patients

Joo Youn Yang, M.D., Ho Youn Lee, M.D., Nam Hee Kim, M.D., Youn Seup Kim, M.D.

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.

Address for correspondence: Youn Seup Kim, M.D., Department of Internal Medicine, Dankook University College of Medicine 16-5, Anseo-dong Cheonan, 330-715, Korea. Phone: 041-550-3911, Fax: 041-556-3256, drys99@dankook.ac.kr

Received 25 July 2006       Accepted 16 August 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Recent studies have suggested an association between chronic cough and gastroesophageal reflux. Our study aimed to assess the utility of a proton-pump inhibitor in unexplained chronic cough patients.

Methods

Patients with chronic cough of unknown etiology were evaluated using a chest x-ray, methacholine challenge test, and an empirical trial of postnasal drip therapy. After excluding other potential causes of the cough, forty patients were included in the study and treated for 8 weeks with a proton-pump inhibitor.

Results

Eleven and three patients in the first and second 4 weeks were lost to follow-up, leaving twenty-six patients finally included in the study. Of these patients, two were unimproved, eight partially responded to the proton-pump inhibitor and sixteen responded completely after the 8 week treatment.

Conclusion

We suggest that empirical treatment with a proton pump inhibitor in all patients with persistent cough, which is not secondary to asthma or postnasal drip syndrome, represents a practical and simple approach to this ailment.

Keywords: Chronic cough, Gastroesophageal reflux, Proton pump inhibitor

Figures and Tables

Figure 1
Algorithm of chronic cough study protocol, illustrating total number of patients evaluated and follow-up lossed.
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Figure 2
Response of proton pump inhibitors treatment at 4weeks and 8weeks.
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Figure 3
Response of proton pump inhibitors treatment on follow loss patients.
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