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Na, Oh, Choi, Seo, and Kim: Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Chronic Obstructive Pulmonary Disease in Korean Population
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 60(6): 638-644.

Published online: 30 June 2006

DOI: https://doi.org/10.4046/trd.2006.60.6.638

Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Chronic Obstructive Pulmonary Disease in Korean Population

Joo Ock Na, M.D., Myung Ho Oh, M.D.1, Jae Sung Choi, M.D., Ki Hyun Seo, M.D., Yong Hoon Kim, M.D.

Department of Internal Medicine, Soonchunhyang University Collage of Medicine, Cheonan, Korea.

1Department of Pediatrics, Soonchunhyang University Collage of Medicine, Cheonan, Korea.

Address for correspondence: Joo Ock Na, M.D. Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University Collage of Medicine 23-20, Bongmyeong-dong, Cheonan, 330-721 Korea. Phone: 041-570-3666, Fax: 041-570-5762, juokna@schch.co.kr

Received 18 April 2006       Accepted 16 June 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Backgrounds

This study investigated whether or not a polymorphism in the gene encoding the surfactant protein A(SP-A) has any bearing on the individual susceptibility to the development of chronic obstructive pulmonary disease(COPD) in a genetically homogenous Korean population.

Methods

The genotypes of 19 COPD patients and 20 healthy neonates as controls were tested using a polymerase chain reaction followed by restriction fragment length polymorphism analysis for the SP-A gene.

Results

The specific frequencies of the 6A2 and 6A18 alleles of SP-A1 and the 1A2 allele of SP-A2 were much higher in the COPD group than control group (p<0.05). However, the frequencies of the 6A3 and 6A4 alleles of SP-A1 and the 1A0 allele of SP-A2 in the COPD group were significantly lower than the control group. In the COPD group, the frequencies of the +50 locus genotypes GG of SP-A1 and the +9 locus genotypes CC of SP-A2 were 85.0% and 60.6%, respectively, and 19.7% and 24.8% in the control group, respectively. The frequencies of the polymorphic genotypes or alleles showed a statistically significant difference between the COPD group and the control group (P<0.05).

Conclusion

A genetic polymorphism in SP-A is associated with the development of COPD in the Korean population.

Keywords: Surfactant, SP-A, SP-A alleles, Genotype of SP-A, COPD, Genetic polymorphism

Figures and Tables

Figure 1
Distribution of the SP-A1 alleles in the COPD and control
trd-60-638-g001
Figure 2
Distribution of the SP-A2 alleles in the COPD and control
trd-60-638-g002
Table 1
Clinical features of 19 patients sith COPD*
trd-60-638-i001

*COPD: chronic obstructive pulmonary disease

Table 2
Frequencies of SP-A genotypes in COPD and control
trd-60-638-i002

OR†: Odd ratios CI†: Confidence intervals

Table 3
Analysis of SP-A nucleotides in COPD and control
trd-60-638-i003

*p Value < 0.0.5

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