Journal List > Tuberc Respir Dis > v.60(4) > 1000941

Ra, Lee, Jung, Kang, Park, Choi, Jung, Chon, and Shim: Mycobacterium Kansasii Disease Presenting As a Lung Mass and Bronchial Anthracofibrosis

Abstract

The incidence of Mycobacterium kansasii pulmonary diseases are on the increase in Korea with the higher probability of occurrence in middle-aged and older men with underlying lung diseases Among nontuberculosus mycobacterial (NTM) infections, the clinical features of M. kansasii pulmonary infection are most similar to those of tuberculosis (TB). The chest radiographic findings of M. kansasii infection are almost indistinguishable from those of M. tuberculosis (predominance of an upper lobe infiltration and cavitary lesions), even though some suggest that cavities are more commonly thin-walled and have less surrounding infiltration than those of typical TB lesions.
Although there are reports on the rare manifestations of M. kansasii infections, such as endobronchial ulcer, arthritis, empyema, cutaneous and mediastinal lymphadenitis, cellulites and osteomyelitis, the association with bronchial anthracofibrosis has not yet been reported.
This report describes the first case of M. kansasii infection presenting as a lung mass in the right lower lobe with accompanying bronchial anthracofibrosis.

Figures and Tables

Figure 1
Chest X ray and CT finding at initial evaluation.
A. Chest radiograph. B. Chest CT scan.
trd-60-464-g001
Figure 2
Bronchoscopic findings of bronchial anthracofibrosis and stenosis in the anterior segment of right upper lobe bronchus. Bronchial anthracofibrosis was found in multiple segments of bronchial trees.
trd-60-464-g002

References

1. American Thoracic Society. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med. 1997. 156:S1–S25.
2. Yim JJ, Park YK, Lew WJ, Bai GH, Han SK, Shim YS. Mycobacterium kansasii pulmonary diseases in Korea. J Korean Med Sci. 2005. 20:957–960.
3. Griffith DE. Management of disease due to Mycobacterium kansasii. Clin Chest Med. 2002. 23:613–621.
4. Koh WJ, Kwon OJ, Suh GY, Chung MP, Kim HJ, Lee NY, et al. A case report of three patients with nontuberculous mycobacterial pulmonary disease caused by Mycobacterium kansasii. Tuberc Respir Dis. 2003. 54:459–466.
5. Scientific Committee in Korean Academy of Tuberculosis and Respiratory Diseases. National survey of mycobacterial diseases other than tuberculosis in Korea. Tuberc Respir Dis. 1995. 42:277–294.
6. Maliwan N, Zvetina JR. Clinical features and follow up of 302 patients with Mycobacterium kansasii pulmonary infection: a 50 year experience. Postgrad Med J. 2005. 81:530–533.
7. Aberg JA, Yajko DM, Jacobson MA. Eradication of AIDS-related disseminated Mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy. J Infect Dis. 1998. 178:1446–1449.
8. Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, Israel HL, et al. Infection with Mycobacterium avium complex in patients without predisposing conditions. N Engl J Med. 1989. 321:863–868.
9. Park SY, Park JH, Jegal YJ, Lee JH, Lim CM, Lee SD, et al. A case of idiopathic CD4+ T-lymphocytopenia with disseminated Mycobacterium kansasii infection and pulmonary alvelolar proteinosis. Tuberc Respir Dis. 2000. 48:377–382.
10. Bloch KC, Zwerling L, Pletcher MJ, Hahn JA, Gerberding JL, Ostroff SM, et al. Incidence and clinical implications of isolation of Mycobacterium kansasii: results of a 5-year, population-based study. Ann Intern Med. 1998. 129:698–704.
11. Corbett EL, Blumberg L, Churchyard GJ, Moloi N, Mallory K, Clayton T, et al. Nontuberculous mycobacteria: defining disease in a prospective cohort of South African miners. Am J Respir Crit Care Med. 1999. 160:15–21.
12. Ahn CH, Lowell JR, Ahn SS, Ahn S, Hurst GA. Chemotherapy for pulmonary disease due to Mycobacterium kansasii: efficacies of some individual drugs. Rev Infect Dis. 1981. 3:1028–1034.
13. Witzig RS, Fazal BA, Mera RM, Mushatt DM, Dejace PM, Greer DL, et al. Clinical manifestations and implications of coinfection with Mycobacterium kansasii and human immunodeficiency virus type 1. Clin Infect Dis. 1995. 21:77–85.
14. Manali ED, Tomford WJ, Liao DW, Farver C, Mehta AC. Mycobacterium kansasii endobronchial ulcer in a nonimmunocompromised patient. Respiration. 2005. 72:305–308.
TOOLS
Similar articles