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Yang, Roh, Lee, Kim, Lee, Choi, Bang, Kim, Seo, Kim, Kim, Lee, and Son: The Relationship between Heme Oxygenase-1 Expression and Response to Cisplatin Containing Chemotherapy in Advanced Non-Small Cell Lung Cancer
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 60(3): 314-320.

Published online: 31 March 2006

DOI: https://doi.org/10.4046/trd.2006.60.3.314

The Relationship between Heme Oxygenase-1 Expression and Response to Cisplatin Containing Chemotherapy in Advanced Non-Small Cell Lung Cancer

Doo Kyung Yang, M.D., Mee Sook Roh, M.D.1, 2, Kyung Eun Lee, M.D.2, Ki Nam Kim, M.D.3, Ki Nam Lee, M.D.3, Pil Jo Choi, M.D.4, Jung Hee Bang, M.D.4, Bo Kyung Kim, M.D., Hyo Rim Seo, M.D., Min Ji Kim, M.D., Seul Ki Kim, M.D., Soo-Keol Lee, M.D., Choon Hee Son, M.D.

Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

1Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

2Medical Research Center for Cancer Molecular Therapy, Dong-A University College of Medicine, Busan, Korea.

3Department of Radiology, Dong-A University College of Medicine, Busan, Korea.

4Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine, Busan, Korea.

Address for correspondence: Choon Hee Son, M.D., Department of Internal Medicine, Dong-A University College of Medicine, 3-ga Dongdaesin-dong, Seo-gu, Busan, Korea. Phone: 051-240-2874, Fax: 051-240-2963, chshon@dau.ac.kr

Received 26 December 2005       Accepted 14 March 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

The overall response (20-30%) to chemotherapy in non-small cell lung cancer (NSCLC) is quite poor. Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme degradation. There is increasing evidence suggesting that the induction of HO-1 might have an important protective effect against oxidative stress including cisplatin containing chemotherapy. This study retrospectively investigated the relationship between HO-1 expression and the response to chemotherapy containing cisplatinin advanced NSCLC patients.

Material and Methods

The medical records including the responses to chemotherapy of fifty nine cases were evaluated retrospectively, and the tissue samples of these patients were immunohistochemically stained for HO-1.

Results

Forty three of the fifty nine patients(72.8%) showed positive staining for HO-1 in their cancer tissues. There was no significant difference according to the cell type, stage and tumor size. In addition, there was no correlation between HO-1 expression and the responses to chemotherapy.

Conclusion

HO-1 expression in tumor tissue dose not predict the response to cisplatin containing chemotherapy in advanced NSCLC. Further prospective studies with a larger number of patients will be needed to confirm these results.

Keywords: Heme oxygenase-1, Non-small cell lung cancer, Cisplatin containing chemotherapy

Figures and Tables

Figure 1
Immunohistochemical staining for HO-1. (A) negative HO-1 expression (×200), (B) positive HO-1 expression in adenocarcinoma (×200), (C) positive HO-1 expression in squamous cell carcinoma (×200), (D) positive HO-1 expression in non-small cell lung cancer (×200).
trd-60-314-g001
Table 1
Patients Characteristics
trd-60-314-i001

*TP : docetaxel + cisplatin,

†NIP : vinorelbin + ifosphamide + cisplatin,

‡MIP : mitomycin + ifosphamide + cisplatin,

§VP : etoposide + cisplatin

Table 2
Correlation of clinical factors with HO-1
trd-60-314-i002
Table 3
Correlation of clinical factors and HO-1 with response to chemotherapy.
trd-60-314-i003

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