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Cho, Lee, Cho, Na, and Han: The Correlation between the Radiological Changes and the Level of Transforming Growth Factor-β1 in Patients with Pulmonary Tuberculosis
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 60(3): 297-303.

Published online: 31 March 2006

DOI: https://doi.org/10.4046/trd.2006.60.3.297

The Correlation between the Radiological Changes and the Level of Transforming Growth Factor-β1 in Patients with Pulmonary Tuberculosis

Yongseon Cho, M.D., Yang Deok Lee, M.D., Wook Cho, M.D., Dong Jib Na, M.D., Min Soo Han, M.D.

Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.

Address for correspondenced: Yang Deok Lee, M.D., Department of Internal Medicine, Eulji University Hospital, 1306 Doonsan-Dong, Seo-Gu, Daejeon, Korea, 302-799. Phone: 82-42-611-3154, Fax: 82-42-259-1111, lydmd@hanmail.net

Received 23 February 2006       Accepted 14 March 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Pulmonary tuberculosis is frequently accompanied with complications such as bronchiectasis, cavities, fibrosis and a deterioration of the lung function. However, there is little information available on the pathogenesis of these complications in pulmonary tuberculosis. Among the many factors involving in tissue remodeling, transforming growth factor-β1 (TGF-β1) is a potent stimulus of the extracellular matrix fomation and a mediator of potential relevance for airway wall remodeling. Therefore, this study examined the relationship between the radiological changes and the TGF-β1 level in patients with pulmonary tuberculosis.

Methods

Serum and bronchoalveolar lavage fluid (BALF) were collected from total of 35 patients before treating them for active pulmonary tuberculosis, and the TGF-β1 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BALF levels were recalculated as the epithelial lining fluid (ELF) levels using the albumin method. pulmonary function test (PFT) and high resolution computed tomography (HRCT) were performed before and after treatment.

Results

There was a strong correlation between the serum TGF-β1 level and the presence of cavities (r=0.404, p=0.006), even though the BAL TGF-β1 level showed a weak correlation with complications. In addition, there was no correlation between the TGF-β1 levels before treatment and the changes in the PFT and HRCT during treatment.

Conclusion

There is a correlation between the serum TGF-β1 level and cavity formation in pulmonary tuberculosis before treatment. However, further study will be needed to confirm this.

Keywords: Pulmonary tuberculosis, TGF-β1, Cavity, High resolution computed tomography

Figures and Tables

Figure 1
Correlation between TGF-β1 levels of serum and cavity score by HRCT
trd-60-297-g001
Table 1
Changes of the radiologic score by HRCT and PFT
trd-60-297-i001

Radiologic score are presensented as median, range and PFT are presented as mean±SD.

Abbreviation: HRCT, high resolution computed tomography; PFT, pulmonary function test; Tx, treatment; FVC, forced vital capacity; FEV1, forced expiratory volume in one second

Table 2
Differences of TGF-β1 levels in BALF and serum before treatment, subdivided into two groups according to the changes HRCT score and PFT after treatment
trd-60-297-i002

Data are presensented as median, range. BALF levels were recalculated as epithelial lining fluid levels by the albumin method. Abbreviation: BALF, bronchoalveolar lavage fluid; HRCT, high resolution computed tomography; PFT, pulmonary function test; FVC, forced vital capacity; FEV1, forced expiratory volume in one second

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