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Jung, Park, Hong, Oh, Lim, Lee, Koh, Kim, Kim, Kim, and Shim: The Clinical Characteristics, Diagnosis, Treatment, and Outcomes of Patients with Tuberculosis at a Private University Hospital in Korea
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2006; 60(2): 194-204.

Published online: 28 February 2006

DOI: https://doi.org/10.4046/trd.2006.60.2.194

The Clinical Characteristics, Diagnosis, Treatment, and Outcomes of Patients with Tuberculosis at a Private University Hospital in Korea

Young Ju Jung, M.D., I-Nae Park, M.D., Sang Bum Hong, M.D., Yeon-Mok Oh, M.D., Chae-Man Lim, M.D., Sang Do Lee, M.D., Younsuck Koh, M.D., Woo Sung Kim, M.D., Dong Soon Kim, M.D., Won Dong Kim, M.D., Tae Sun Shim, M.D.

Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Address for correspondence: Tae Sun Shim, MD. Address: Division of Pulmonary & Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-Dong, Songpa-Ku, Seoul, 138-736, South Korea. Phone: 02-3010-3892, 016-9290-5825, Fax: 02-3010-6968, shimts@amc.seoul.kr

Received 1 December 2005       Accepted 31 January 2006

Copyright © 2006 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Even though tuberculosis (TB) is still a major public concern in Korea, there is little data on the management of TB patients and its outcomes in the private sector. This study evaluated the status of TB treatment in the private sector.

Methods

Sixteen-hundred-sixty-six TB patients who were notified in a private university hospital from 2001 to 2002 were enrolled in this study. The patients were divided into pulmonary (TBP), extrapulmonary (TBE), and combined (TBP+E) groups, and were also divided into initial and retreatment groups. The clinical characteristics, diagnostic methods, treatment regimens, and outcomes were analyzed and compared.

Results

The mean age of the 1,666 patients was 48.9 years and the male-to-female ratio was 1.3:1. The number of patients in the initial and retreatment groups of TBP, and those of (TBE + TBP+E) were 809, 276, 480, 101, respectively. A bacteriological study was performed in 92.0% of cases, and a positive culture was confirmed in 58.1% and 31.7% of patients with TBP and (TBE + TBP+E), respectively (p<0.05). The AFB smear was positive in 45.4 % of the TBP patients. PCR was carried out in 60.4% of the (TBE + TBP+E) group. The MDR was detected in 14.0% of isolates. Overall, the treatment completion, default, and death rates were 70.2%, 13.5% and 1.9%, respectively.

Conclusion

Even though the management of TB patients in a private hospital was satisfactory in terms of the national guidelines, the high default rate was is still a problem. Efforts to decrease the default rate either independently or in cooperation with the public sector will be needed.

Keywords: Tuberculosis, Private Sector, Korea, Diagnosis, Treatment, Treatment outcome

Figures and Tables

Table 1
Clinical characteristics of patients.
trd-60-194-i001

*TBP: Pulmonary tuberculosis

†TBE + TBE+P : Extrapulmonary and combined tuberculosis, ‡Tx: Treatment

Table 2
Involved organs of extrapulmonary tuberculosis.
trd-60-194-i002

*TBE: Extrapulmonary tuberculosis

†TBE+p: Combined tuberculosis

Table 3
Diagnostic methods and susceptibility test results.
trd-60-194-i003

*TBP: Pulmonary tuberculosis

†TBE + TBE+P : Extrapulmonary and combined tuberculosis

‡Tx: Treatment

§:P<0.05 compared between Initial-Tx and Re-Tx groups.

∥:P<0.05 compared between TBP and (TBE + TBE+P) groups

Table 4
Antituberculous regimens and side effects of drugs.
trd-60-194-i004

*TBP: Pulmonary tuberculosis

†TBE + TBE+P : Extrapulmonary and combined tuberculosis

‡Tx: Treatment

§:P<0.05 compared between Initial-Tx and Re-Tx groups.

Table 5
Clinical outcomes of total 1,666 and 68 MDR patients.
trd-60-194-i005

*TBP: Pulmonary tuberculosis, †TBE + TBE+P : Extrapulmonary and combined tuberculosis

‡Tx: Treatment

§P<0.05 compared between Initial-Tx and Re-Tx groups

∥MDR: Multi-drug resistance

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