Journal List > Tuberc Respir Dis > v.59(5) > 1000866

TOOLS
Cho, Nam, Lee, Yoon, Ryu, Kwak, and Lee: Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions
Original Article

Tuberculosis and Respiratory Diseases 2005; 59(5): 517-521.

Published online: 30 November 2005

DOI: https://doi.org/10.4046/trd.2005.59.5.517

Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions

Jae Hwa Cho1, Jeong Hyeon Nam2, Kyum Ho Lee1, Byeong Kab Yoon1, Jeong Sun Ryu1, Sung Min Kwak1, Hong Lyeol Lee1

1Department of Internal Medicine, College of Medicine, Inha University, Incheon, Republic of Korea. jaehwa.

2Department of Clinical Pathology, College of Medicine, Inha University, Incheon, Republic of Korea.

Address for correspondence: Jae Hwa Cho, M.D. Department of Internal Medicine, College of Medicine, Inha University, 7-206, 3-ga, Shinheung-dong, Jung-gu, Incheon, 400-711, Republic of Korea. Phone: +82-32-890-3490, Fax : +82-32-882-6578, jaehwa.cho@inha.ac.kr

Received 2 May 2005       Accepted 21 September 2005

Copyright©2005. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions.

Methods

The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay.

Results

The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates.

Conclusion

Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.

Keywords: Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase

TOOLS
Similar articles