Journal List > Tuberc Respir Dis > v.59(5) > 1000862

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Yoo, Kim, Eom, Shin, Park, Lee, Jang, Bahn, Kim, Park, Lee, Hyun, Lee, and Jung: The Role of Respiratory Viral Infections in Exacerbation of Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Original Article

Tuberculosis and Respiratory Diseases 2005; 59(5): 497-503.

Published online: 30 November 2005

DOI: https://doi.org/10.4046/trd.2005.59.5.497

The Role of Respiratory Viral Infections in Exacerbation of Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Ji Youn Yoo, M.D., Dong-Gyu Kim, M.D., Kwang-Seok Eom, M.D., Taerim Shin, M.D., Yong Bum Park, M.D., Jae Young Lee, M.D., Seung Hun Jang, M.D., Joon-Woo Bahn, M.D., Cheol Hong Kim, M.D., Sang Myeon Park, M.D., Myung Goo Lee, M.D., In-Gyu Hyun, M.D., Kyu Man Lee, M.D.1, Ki-Suck Jung, M.D.

Department of Internal medicine, Hallym University College of Medicine, Anyang, Korea.

1Department of Pathology, Hallym University College of Medicine, Anyang, Korea.

Address for correspondence: Ki-Suck Jung, M.D. Division of Pulmonology and Critical Cared Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896 Pyungchon-dong, Dongan-gu, Anyang-si, Gyeonggi-do, 431-070, Republic of Korea. Phone: 82-31-380-3715, Fax: 82-31-380-3973, pulmoks@hallym.ac.kr

Received 4 April 2005       Accepted 14 September 2005

Copyright©2005. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Backgrounds

The exacerbations of asthma and chronic obstructive pulmonary disease (COPD) have been suggested to be associated with respiratory tract viral infections (RTVIs). However, the rates of virus detection in previous studies have been quite variable, with lower rates for the exacerbation of COPD. Therefore, the virus detection of patients with exacerbation of asthma and COPD were investigated.

Methods

20 and 24 patients with exacerbation of asthma and COPD, respectively, were enrolled. Nasal and sputum samples were taken, and polymerase chain reaction (PCR) for rhinovirus and coronavirus and virus culture for influenza A, B, RSV and parainfluenza virus performed.

Results

The mean FEV1/FVC in the exacerbation of asthma and COPD patients were 1.9/2.9 L (65.5%) and 1.1/2.6 L (42.3%), respectively. Respiratory virus was detected in 13 (65%) patients with exacerbation of asthma and rhinovirus was detected in 9. Coronavirus, influenza A, RSV and parainfluenza virus were detected in 2, 2, 1 and 1 patients with asthma. Among patients with exacerbation of COPD, a virus was detected in 14 (58.3%) patients, with rhinovirus, coronavirus and influenza A detected in 10, 3 and 4, respectively.

Conclusions

This study suggested that RTVIs may have a role in the exacerbation of COPD as well as asthma.

Keywords: Asthma, Chronic obstructive pulmonary Disease (COPD), Exacerbation, Viral infection

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