Journal List > Tuberc Respir Dis > v.59(3) > 1000832

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Cho, Cho, Lee, Park, and Cho: M. tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects
Original Article

Tuberculosis and Respiratory Diseases 2005; 59(3): 272-278.

Published online: 30 September 2005

DOI: https://doi.org/10.4046/trd.2005.59.3.272

M. tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects

Jang Eun Cho1, Sang Nae Cho1, Kyung Wha Lee2, Seung Kyu Park3, Sungae Cho1, *

1Department of Microbiology, Brain Korea 21 project for Medical Sciences, Yonsei University Medical Center, Korea.

2Hallym Institution for Genome Application Hallym University, Korea.

3National Masan Tuberculosis Hospital, Korea.

Address for correspondence: Sungae Cho, Ph.D. Department of Microbiology, Yonsei University Medical Center 134 Seodaemoon-ku, Shinchon-dong 120-749 Seoul, Korea. Phone: 02-2228-1831, Fax: 02-392-9310

Current address:

*Current address: Institut Pasteur Korea, 39-1 Hawolgok-dong, Seongbuk-gu 136-791 Seoul, Korea. Phone: 02-3299-0322, Fax: 02-3299-0210, scho@pasteur.or.kr

Received 16 June 2005       Accepted 26 August 2005

Copyright©2005. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects.

Methods

Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects.

Results

The results indicate the cytotoxic and IFN-γ immune responses of CD8+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects.

Conclusion

The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

Keywords: CD8+T cells, cytotoxicity, M. tuberculosis somatic antigens

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