Journal List > Tuberc Respir Dis > v.58(1) > 1000761

TOOLS
Kim, Choi, Park, Lee, Lee, and Rhee: Polymorphisms of Angiotensin-converting Enzyme Gene Associated in Patients with COPD with or without Bronchial Hyperresponsiveness
Original Article

Tuberculosis and Respiratory Diseases 2005; 58(1): 25-30.

Published online: 31 January 2005

DOI: https://doi.org/10.4046/trd.2005.58.1.25

Polymorphisms of Angiotensin-converting Enzyme Gene Associated in Patients with COPD with or without Bronchial Hyperresponsiveness

Seung Soo Kim, M.D.1, Eu Gene Choi, M.D.2, Seoung Ju Park, M.D.3, Heung Bum Lee, M.D.3, Yong Chul Lee, M.D.3, Yang Keun Rhee, M.D.3

1Department of Internal Medicine, College of Medicine, The Catholic University of Korea.

2Department of Internal Medicine, College of Medicine, Konyang University, Korea.

3Department of Internal Medicine, Medical School, Chonbuk National University, Korea.

4Research Institute of Clinical Medicine, Chonbuk National University, Korea.

Heung-Bum Lee, MD. PhD. Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Keum-Am Dong, Jeonju, Jeonbuk, 561-712, Korea. Phone: +82-63-250-1660, Fax: +82-63-254-1609, lhbmd@chonbuk.ac.kr

Received 22 September 2004       Accepted 4 November 2004

Copyright©2005. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and occurrence according to ACE gene insertion (I)/deletion (D) polymorphism. Also, the involvement of the ACE genes as the genetic basis of bronchial asthma is currently controversy. We investigated whether there was any association between polymorphisms of the ACE genes and airway hyper-responsiveness in chronic obstructive pulmonary disease (COPD).

Methods

A total of 100 patients with COPD were enrolled in this study. The ACE genotypes were determined in all subjects by polymerase chain reaction. Pulmonary function test including bronchodilator response (BDR), methacholine bronchial provocation test (MBPT) were done in those patients. Airway hyper-responsiveness include any findings of positive BDR or MBPT.

Results

In COPD patients, the ACE genotype distribution did not differ significantly among groups of patients with severities of COPD, and with or without airway hyper-responsiveness.

Conclusions

These results suggest that polymorphisms of the ACE gene may not be associated with airway hyper-responsiveness, development and severity of COPD.

Keywords: Angiotensins, Enzymes, Polymorphism, COPD

TOOLS
Similar articles