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Song, Kim, Kwon, Kim, Kim, Moon, Song, and Park: Nuclear Factor-κB (NF-κB) Activity and Levels of IL-6, IL-8 and TNF-α in Induced Sputum in the Exacerbation and Recovery of COPD Patients
Original Article

Tuberculosis and Respiratory Diseases 2005; 58(2): 152-159.

Published online: 28 February 2005

DOI: https://doi.org/10.4046/trd.2005.58.2.152

Nuclear Factor-κB (NF-κB) Activity and Levels of IL-6, IL-8 and TNF-α in Induced Sputum in the Exacerbation and Recovery of COPD Patients

So Hyang Song, M.D., Chi Hong Kim, M.D., Soon Seog Kwon, M.D., Young Kyoon Kim, M.D., Kwan Hyoung Kim, M.D., Hwa Sik Moon, M.D., Jeong Sup Song, M.D., Sung Hak Park, M.D.

Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea 93 Chi-dong, Paldal-ku, Suwon, 442-723, Korea.

Address for correspondence: Chi Hong Kim, M.D. Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea 93 Chi-dong, Paldal-ku, Suwon, 442-723, Korea. Phone: 031-249-7361, Fax: 031-253-8898, chihongk@yahoo.co.kr

Received 29 November 2004       Accepted 1 February 2005

Copyright©2005. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-κB is known to be an indicator of cellular activation and of inflammatory mediator production. This study was undertaken to investigate the change of cytokine characteristics and NF-κ B activity in induced sputum of COPD patients during exacerbation and recovery of the disease.

Methods

Sputum induction was performed in 37 patients with COPD during exacerbation and during recovery and in 15 healthy subjects. Cell counts, levels of IL-6, IL-8 and TNF-α in induced sputum and NF-κB activity in macrophage of induced sputum were measured.

Results

Patients with COPD showed significantly increased levels of IL-6, IL-8 and TNF-α(p<0.01) and increased NF-κB activity in induced sputum(p<0.05) as compared with control subjects. Level of IL-8 during exacerbation of COPD decreased significantly during recovery(p<0.05). NF-κB activity and levels of IL-6 and TNF-α tended to be decreased during recovery, but not siginificantly.

Conclusion

Activation of NF-κB and increased levels of IL-6, IL-8 and TNF-α were thought to be associated with pathogenesis and exacerbations of COPD.

Keywords: COPD, exacerbation, NF-κB, IL-6, IL-8, TNF-α

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