Abstract
Primary malignant lymphomas in the female genital tract are rare, but when it occurs, the cervix or the ovary are more common site than the uterine corpus. Most common symptoms are abnormal vaginal bleeding but sometimes it is symptom free. Due to rarity of primary malignant lymphoma, the standard treatments are not yet established, but rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy after the surgery is general executed. We present a case of primary malignant lymphoma originating from endometrium with spine involvement.
References
1. Upanal N, Enjeti A. Primary lymphoma of the uterus and cervix: two case reports and review of the literature. Aust N Z J Obstet Gynaecol. 2011. 51:559–562.
2. Latteri MA, Cipolla C, Gebbia V, Lampasona G, Amato C, Gebbia N. Primary extranodal non-Hodgkin lymphomas of the uterus and the breast: report of three cases. Eur J Surg Oncol. 1995. 21:432–434.
3. Gurbuxani S, Anastasi J, Hyjek E. Diffuse large B-cell lymphoma: more than a diffuse collection of large B cells: an entity in search of a meaningful classification. Arch Pathol Lab Med. 2009. 133:1121–1134.
4. Jørgensen JM, Sørensen , Sorensen FB, Bendix K, Nielsen JL, Olsen ML, Funder AM, et al. Angiogenesis in non-Hodgkin's lymphoma: clinico-pathological correlations and prognostic significance in specific subtypes. Leuk Lymphoma. 2007. 48:584–595.
5. Fox H, More JR. Primary malignant lymphoma of the uterus. J Clin Pathol. 1965. 18:723–728.
6. Frey NV, Svoboda J, Andreadis C, Tsai DE, Schuster SJ, Elstrom R, et al. Primary lymphomas of the cervix and uterus: the University of Pennsylvania's experience and a review of the literature. Leuk Lymphoma. 2006. 47:1894–1901.
7. Lee WM, Lee JE, Hwang JH. Malignant lymphoma originated from uterine cervix and extended to endometrium: a case report. Korean J Gynecol Oncol. 2005. 16:361–365.
8. Cheong IJ, Kim SH, Park CM. Primary uterine lymphoma: a case report. Korean J Radiol. 2000. 1:223–225.
9. Suzuki Y, Tamaki Y, Hasegawa M, Maebayashi K, Mitsuhashi N. Magnetic resonance images of primary malignant lymphoma of the uterine body: a case report. Jpn J Clin Oncol. 2000. 30:519–521.
10. Baba S, Abe K, Isoda T, Maruoka Y, Sasaki M, Honda H. Impact of FDG-PET/CT in the management of lymphoma. Ann Nucl Med. 2011. 25:701–716.
11. Kim YS, Koh BH, Cho OK, Rhim HC. MR imaging of primary uterine lymphoma. Abdom Imaging. 1997. 22:441–444.
12. Moskowitz C. Diffuse large B cell lymphoma: how can we cure more patients in 2012? Best Pract Res Clin Haematol. 2012. 25:41–47.
13. Shen CJ, Tsai EM, Tsai KB, Wu CH, Hsu SC. Primary T-cell lymphoma of the uterine corpus. Kaohsiung J Med Sci. 2007. 23:138–141.
14. Plosker GL, Figgitt DP. Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs. 2003. 63:803–843.
15. Marcus R, Hagenbeek A. The therapeutic use of rituximab in non-Hodgkin's lymphoma. Eur J Haematol Suppl. 2007. (67):5–14.