Cheol Min Jang; Seul Ki Kim; Nam Hee Kim; Shin Yeoung Lee; Kyung Mo Yoo; Tae Hoon Lee; Hyun Beom Chae; Ki Joong Han; Eun Jeong Joo; Joong Kyong Ahn

doi:10.4078/jrd.2015.22.3.175

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Jang, Kim, Kim, Lee, Yoo, Lee, Chae, Han, Joo, and Ahn: A Case of Sweet's Syndrome Diagnosed Concomitantly with Sjögren's Syndrome

Case Report

J Rheum Dis 2015;22(3):175-179.

Published online: 31 October 2015

DOI: https://doi.org/10.4078/jrd.2015.22.3.175

A Case of Sweet's Syndrome Diagnosed Concomitantly with Sjögren's Syndrome

Cheol Min Jang, Seul Ki Kim, Nam Hee Kim, Shin Yeoung Lee, Kyung Mo Yoo, Tae Hoon Lee, Hyun Beom Chae, Ki Joong Han, Eun Jeong Joo, Joong Kyong Ahn

Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Corresponding to: Joong Kyong Ahn, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Korea. E-mail: mdahnjk@skku.edu

Received 9 June 2014 Revised 27 June 2014 Accepted 27 June 2014

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sweet's syndrome is an uncommon reactive dermatoses characterized by fever, polymorphonuclear leukocytosis, painful erythematous plaques, and dense dermal infiltrate of neutrophils. Sweet's syndrome can be associated with several diseases, including infectious diseases, malignant tumors, and autoimmune diseases. However, no case of Sweet's syndrome associated with Sjögren's syndrome (SjS) has been reported in Korea. A 44-year-old woman presented with acute pustular rashes and fever. The patient had multiple papulopustular skin rashes, and complained of fever, chills, and headache. Our patient had the characteristic clinical and histopathological features of Sweet's syndrome, in association with SjS, diagnosed by salivary gland scan, positive anti-SS-A/SS-B antibody, and sicca symptoms simultaneously. Thus, we report on a case of a patient with Sweet's syndrome with concomitant diagnosis of SjS.

Keywords: Sweet syndrome, Sjögren's syndrome

REFERENCES

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Figure 1.

Erythematous papulopustular rash over face (A), neck (B), left forearm (C), and right auricle (D).

Figure 2.

(A) Diffuse swelling and perimuscular inflammatory infiltration of the left psoas muscle. (B) After treatment of Sweet's syndrome, significant remission of swelling and perimuscular inflammatory infiltration has occurred.

Figure 3.

The salivary gland scan shows decreased uptake and delayed washout of the radiotracer by both parotid glands and both submandibular glands. This finding suggests primary Sjögren's syndrome. ANT: anterior view, LAT: lateral view, LT: left, RT: right, PG: parotid gland, EF: ejection fraction, SMG: submandibular gland.

Figure 4.

(A) The epidermis desquamated and diffuse infiltration of inflammatory cells in deep dermis (H&E, ×40). (B) An infiltration of predominantly neutrophils, without evidence of vasculitis (H&E, ×400).

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