Journal List > Tuberc Respir Dis > v.70(4) > 1001610

Song, Sohn, Kwak, Kim, Lee, Kim, Kim, Yoon, Shin, and Park: Clinicopathologic Characteristics of Recurrence after Curative-intent Surgical Therapy of Non-small Cell Lung Cancer

Abstract

Background

The clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC) have been changing. Recently, Positron emission tomography-computed tomography (PET-CT) has usually been used for diagnosis, follow-up to treatment and surveillance of NSCLC. We studied the pattern of recurrence and prognosis in patients who underwent complete resection for NSCLC according to histologic subtype.

Methods

All patients who underwent complete resection for pathological stage I or II NSCLC between January 2005 and June 2009 were identified and clinical records were reviewed retrospectively, especially the histologic subtype.

Results

Recurrences were identified in 50 of 112 patients who had complete resection of an NSCLC. Sites of recurrence were locoregional in 15 (30%), locoregional and distant in 20 (40%), and distant in 15 (30%). Also, sites of recurrence were intra-thoracic in 29 (58%), extrathoracic and intra-thoracic recurrence in 15 (30%), and extrathoracic in 6 (12%). In locoregional recurrence, there was 37% recurrence for non-squamous cell carcinoma (non-SQC) and 25% for squamous cell carcinoma (SQC). In distant recurrence, there was 39% recurrence for non-SQC and 18% for SQC. Locoregional recurrence in the bronchial stump was more common in SQC than non-SQC (14% vs. 45%, p=0.025). Prognosis of recurrence was not influenced by histologic subtype and the recurrence-free survival curve showed that the non-SQC group did not differ from the SQC group according to stage.

Conclusion

The prognosis for recurrence does not seem to be influenced by histologic types, but locoregional recurrence in the bronchial stump seems to be more common in SQC than non-SQC in completely resected stage I and II NSCLC.

Figures and Tables

Figure 1
Recurrence-free survival curve shows that risk of recurrence does not differ between non-squamous and squamous cell carcinoma in stage I. SQC: squamous cell carcinoma.
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Figure 2
Recurrence-free survival curve shows that risk of recurrence does not differ between non-squamous and squamous cell carcinoma in stage II. SQC: squamous cell carcinoma.
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Table 1
Clinicopathologic characteristics of all patients
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*Values are presented as number (%).

Table 2
Clinicopathologic characterisitics of patients with recurrence
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*Values are presented as number (%).

RFS: recurrence free survival.

Table 3
Comparison of site of recurrence between non-squamous and squamous cell carcinoma
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Values are presented as number (%).

SQC: squamous cell carcinoma.

Table 4
Comparison of site of intrathoracic recurrence between non-squamous and squamous cell carcinoma
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Values are presented as number (%).

*Metastasis in ipsilateral peribronchial, ipsilateral hilar, ipsilateral intrapulmonary, ipsilateral mediastinal, ipsilateral subcarinal, contralateral mediastinal, or contralateral hilar lymph nodes.

SQC: squamous cell carcinoma.

Table 5
Comparison of site of extrathoracic recurrence between Non-SQC and SQC
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Values are presented as number (%).

*Metastasis in ipsilateral or contralateral scalen, or supraclavicular lymph nodes.

SQC: squamous cell carcinoma.

Table 6
Univariate analysis for recurrence free survival
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RFS: recurrence-free survival; SQC: squamous cell carcinoma.

Table 7
Multivariate Cox models for recurrence analysis
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OR: odd ratio; CI: confidence interval; SQC: squamous cell carcinoma.

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