Journal List > J Korean Ophthalmol Soc > v.54(2) > 1009601

Lee, Shin, and Lew: A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva

Abstract

Purpose

To report a single case of Rosai-Dorfman disease of the palpebral conjunctiva with a review of the relevant literature.

Case summary

A 39-years-old woman presented with a palpebral conjunctival mass 3 weeks in duration on both eyes. The patient had a history of excisional biopsy of lymphadenitis and wanted to remove the mass for cosmetic reasons. An excisional biopsy was performed to obtain a diagnosis for proper management. The histopathologic examination of the lesion showed an intensive proliferation of monotonous and histiocytoid cells beneath the epidermis. Immunohistochemical staining for the S-100 protein was positive and anti-CD1A antibody was negative. Five months after mass excision, there was no evidence of recurrence.

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Figure 1.
The photograph of the patient's eye before excisional biopsy. Hyperemic and smooth surfaced 25 × 10 mm sized mass was noted at the palpebral conjunctiva of right lower lid.
jkos-54-346f1.tif
Figure 2.
Computed tomographic findings. About 2.8-cm enlarged lymph node (arrow) at the right lateral retropharyngeal space. (A) Small enhancing solid nodule (arrow) at the left nasal cavity (B).
jkos-54-346f2.tif
Figure 3.
Medium power image demonstrating sinus histiocytosis (arrow) with massive lymphadenopathy (H&E, original magnification ×200).
jkos-54-346f3.tif
Figure 4.
M edium power image demonstrating scattered strongly S-100 positive histiocytes within the inflammatory infiltration (S-100, original magnification ×200).
jkos-54-346f4.tif
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