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Shin, Lee, and Uhm: Comparison of Diagnostic Ability of 3D and Stratus Optical Coherence Tomography in Early Glaucoma
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(5): 652-661.

Published online: 16 May 2012

DOI: https://doi.org/10.3341/jkos.2012.53.5.652

Comparison of Diagnostic Ability of 3D and Stratus Optical Coherence Tomography in Early Glaucoma

Joong Won Shin, MD, Won June Lee, MD, Ki Bang Uhm, MD, PhD

Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.

Address reprint requests to Ki Bang Uhm, MD, PhD. Department of Ophthalmology, Hanyang University Medical Center, Seoul, Korea #222 Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea. Tel: 82-2-2290-8570, Fax: 82-2-2291-8517, KBUhm@hanyang.ac.kr

Received 17 August 2011       Accepted 24 March 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To compare the ability of three dimensional spectral-domain optical coherence tomography (3D OCT) and Stratus OCT to detect early glaucoma.

Methods

The optic disc topographic and retinal nerve fiber layer (RNFL) thickness parameters were measured by 3D OCT and Stratus OCT in 69 normal eyes and 48 early glaucoma eyes. The discriminating abilities of the two techniques for detection of glaucoma were compared by the area under the receiver operating characteristic curves (AUC).

Results

The best Stratus OCT parameters and criterion that differentiated normal from early glaucoma based on AUC were horizontal integrated rim width (0.85) for optic nerve head parameters, inferior quadrant (0.88) for RNFL parameters, and ≥1 clock-hour abnormal at the 5% level (0.81) based on the normative database for criteria. The best 3D OCT parameters and criterion that differentiated normal from early glaucoma were vertical cup-to-disc ratio (0.85), 11 o'clock RNFL thickness (0.86), and ≥1 clock-hour abnormal at the 1% level (0.78), respectively. When all corresponding the best parameters and criterion were compared, there were no significant differences between the AUCs for Stratus OCT and 3D OCT (p = 0.95, p = 0.73, p = 0.45, respectively).

Conclusions

Stratus OCT and 3D OCT had similar diagnostic ability for detection of early glaucoma.

Keywords: Glaucoma, Optic nerve, Retinal nerve fiber layer, Spectral-domain optical coherence tomography

Figures and Tables

Figure 1
Comparison of Stratus OCT (A, C) and 3D OCT (B, D) in measurement of peripapillary retinal nerve fiber layer (RNFL) thickness on average, in each of 4 quadrants (A, B), in each of the 12 clock-hour sectors (C, D) between normal group and early glaucoma group. TQ = temporal quadrant; SQ = superior quadrant; NQ = nasal quadrant; IQ = inferior quadrant.
jkos-53-652-g001
Figure 2
Receiver operating characteristic curves of the best parameters and criteria for discriminating between normal eyes and eyes with early glaucoma using Stratus OCT and 3D OCT. RNFLT = retinal nerve fiber layer thickness; CDR = cup-to-disc ratio.
jkos-53-652-g002
Table 1
Demographic and characteristics of study participants
jkos-53-652-i001

Data are expressed as mean ± SD or number.

M = male; F = female; R = right; L = left; MD = mean deviation; PSD = pattern standard deviation.

Table 2
Comparison of Stratus OCT and 3D OCT optic nerve head parameters
jkos-53-652-i002

Data are expressed as mean ± SD.

CDR = cup-to-disc ratio.

Table 3
AUCs of optic nerve head parameters for discriminating between normal eyes and eyes with early glaucoma using Stratus OCT and 3D OCT
jkos-53-652-i003

CI = confidence interval; CDR = cup-to-disc ratio.

Table 4
AUCs of retinal nerve fiber layer thickness parameters for discriminating between normal eyes and eyes with early glaucoma using Stratus OCT and 3D OCT
jkos-53-652-i004

CI = confidence interval.

Table 5
AUCs of criteria based on the normative database for discriminating between normal eyes and eyes with early glaucoma using Stratus OCT and 3D OCT
jkos-53-652-i005

CI = confidence interval; RNFL = retinal nerve fiber layer.

Table 6
Significance level of pairwise comparison of AUCs from the best parameters and criteria for discriminating between normal eyes and eyes with early glaucoma using Stratus OCT and 3D OCT
jkos-53-652-i006

RNFLT = retinal nerve fiber layer thickness; HIRW = horizontal integrated rim width; CDR = cup-to-disc ratio.

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