Comparison of Macular Thickness Measurements Between Fourier-Domain and Time-Domain Optical Coherence Tomography in Normal Eyes and Eyes With Macular Diseases

Byoung Woo Ko; Yong Woon Shin; Jeong Min Lee; Yumi Song; Byung Ro Lee

doi:10.3341/jkos.2009.50.11.1661

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Ko, Shin, Lee, Song, and Lee: Comparison of Macular Thickness Measurements Between Fourier-Domain and Time-Domain Optical Coherence Tomography in Normal Eyes and Eyes With Macular Diseases

Original Article

J Korean Ophthalmol Soc 2009;50(11):1661-1668.

Published online: 31 August 2009

DOI: https://doi.org/10.3341/jkos.2009.50.11.1661

Comparison of Macular Thickness Measurements Between Fourier-Domain and Time-Domain Optical Coherence Tomography in Normal Eyes and Eyes With Macular Diseases

Byoung Woo Ko, MD¹, Yong Woon Shin, MD¹, Jeong Min Lee, MD², Yumi Song, MD¹, Byung Ro Lee, MD¹

¹Department of Ophthalmology, College of Medicine, Hanyang University, Seoul, Korea

²Department of Ophthalmology, GwangMyeong Sungae Hospital, Gwangmyeong, Korea

Address reprint requests to Byung Ro Lee, MD, Department of Ophthalmology, College of Medicine, Hanyang University Hospital #17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Korea Tel: 82-2-2290-8570, Fax: 82-2-2291-8517, E-mail: brlee@hanyang.ac.kr

Received 10 February 2009 Accepted 28 July 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To define and measure macular thickness and volume using Fourier domain OCT (FD OCT) and compare the values with Stratus OCT in normal eyes and eyes with macular disease.

Methods

On the same day, macular thicknesses of the ETDRS 9 subfield and total macular volumes were measured in 35 eyes of 23 normal subjects and 19 diseased eyes of 24 patients with FD OCT and Stratus OCT. The macular cube scan protocol for FD OCT and the fast macular thickness map protocol for Stratus OCT were used to measure macular thicknesses.

Results

Foveal thickness of the central subfield in FD OCT (251.49±79.45 μ m) was thicker than the value of Stratus OCT (210.26 ±60.57 μ m) (p<0.001) in all eyes. Total macular volume was 7.72±1.06 mm³ and 7.04±0.96 mm³ for FD OCT and Stratus OCT, respectively (p<0.001). Retina thickness of the ETDRS 9 subfields in FD OCT was thicker than the value obtained using Stratus OCT. In addition, foveal thickness differences were statistically significant in both the normal and diseased eye groups.

Conclusions

Macular thickness and total macular volume as measured by the FD OCT were larger than the values obtained using the Stratus OCT in both the normal and the diseased eye groups. The measuring algorithm of FD OCT defines the top of RPE as the outer retinal boundary, but Stratus OCT defines the outer retinal boundary as the IS/OS junction of the photoreceptor. Therefore, macular thicknesses of FD OCT are thicker than those of Stratus OCT. This difference should be considered when comparing the results of FD OCT with those of Stratus OCT.

Keywords: Fourier domain OCT, Macular thickness, Macular volume, Stratus OCT

References

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Figure 1.

Six radial scans of Stratus OCT (A) and macular cube scans of Fourier domain OCT (B).

Figure 2.

Comparison of macular thickness measurements in 35 normal eyes (A) and 19 diseased eyes (B) between Fourier domain OCT (FD OCT) and Stratus OCT.

Figure 3.

Fourier domain OCT (FD OCT) and Stratus OCT measurements in all patients (A), normal eyes (B), and diseased eyes (C) are graphed together.

Figure 4.

Outer retinal boundary in Stratus OCT (arrow) and Fourier domain OCT (arrow head). The arrow indicates the inner segment/outer segment photoreceptor junction and the arrow head indicates the inner border of the retinal pigment epithelium.

Table 1.

Comparison of macular thickness measurement in all patients between Fourier domain OCT (FD OCT) and Stratus OCT

ETDRS^* area	FD OCT (μm)	Stratus OCT (μm)	Difference	p-value	r^†
Fovea (500 μm radius)	251.49±79.45	210.26±60.57	41.23±53.87	<0.001	0.74
Inner ring (1.5 mm radius)
Superior	300.54±46.58	273.23±40.79	27.31±30.23	<0.001	0.77
Temporal	292.59±50.41	261.82±50.84	30.77±33.11	<0.001	0.79
Inferior	295.28±44.58	271.56±41.35	23.72±39.60	<0.001	0.58
Nasal	309.08±55.43	272.03±42.60	37.05±43.32	<0.001	0.64
Outer ring (3.0 mm radius)
Superior	264.51±39.94	246.66±36.01	17.85±23.08	<0.001	0.82
Temporal	253.11±47.87	233.56±40.31	19.56±35.22	<0.001	0.69
Inferior	256.51±35.78	237.05±35.25	19.46±33.37	<0.001	0.56
Nasal	286.25±42.65	258.64±39.89	27.61±25.79	<0.001	0.81
Total macular volume (mm³)	7.72±1.06	7.44±1.31	0.67±0.63	<0.001	0.81

OCT=optical coherence tomography

^*Early Treatment Diabetic Retinopathy Study

^†Pearson correlation coefficient.

Table 2.

Comparison of macular thickness measurement in 35 normal eyes and 26 diseased eyes between Fourier domain OCT (FD OCT) and Stratus OCT

ETDRS^* area	FD OCT (μm)	Stratus OCT (μm)	Difference	p-value	r^†
Normal eyes
Fovea (500 μm radius)	223.00±27.49	186.86±21.47	36.14±22.08	<0.001	0.62
Inner ring (1.5 mm radius)
Superior	288.31±17.65	266.49±24.54	21.83±8.74	<0.001	0.89
Temporal	275.31±18.80	252.40±23.22	22.91±18.41	<0.001	0.63
Inferior	284.80±20.24	265.49±20.03	19.31±6.75	<0.001	0.94
Nasal	292.66±20.92	262.29±24.54	30.37±17.88	<0.001	0.70
Outer ring (3.0 mm radius)
Superior	251.31±16.25	236.60±15.60	14.71±9.11	<0.001	0.84
Temporal	234.51±13.88	222.37±23.63	12.14±22.16	<0.001	0.40
Inferior	243.03±15.61	226.06±16.10	16.97±13.17	<0.001	0.66
Nasal	271.11±15.83	246.86±21.17	24.26±18.70	<0.001	0.52
Total macular volume (mm³)	7.26±0.35	6.75±0.40	0.50±0.20	<0.001	0.87
Diseased eyes
Fovea (500 μm radius)	289.85±107.03	241.77±79.86	48.08±78.84	<0.001	0.68
Inner ring (1.5 mm radius)
Superior	317.00±65.52	282.31±57.74	34.69±44.62	<0.001	0.75
Temporal	315.85±68.11	274.50±71.97	41.35±44.35	<0.001	0.80
Inferior	309.38±62.06	279.73±58.63	29.65±60.31	0.004	0.50
Nasal	331.19±76.76	285.15±56.78	46.04±62.63	<0.001	0.60
Outer ring (3.0 mm radius)
Superior	282.27±53.82	260.19±49.48	22.08±33.66	0.003	0.79
Temporal	278.15±64.04	248.62±52.24	29.54±46.15	0.001	0.70
Inferior	274.65±46.31	251.85±47.26	22.81±49.15	0.003	0.45
Nasal	306.62±57.20	274.50±52.47	32.12±32.92	<0.001	0.82
Total macular volume (mm³)	8.32±1.37	7.44±1.31	0.87±0.90	<0.001	0.77

OCT=optical coherence tomography

^*Early Treatment Diabetic Retinopathy Study

^†Pearson correlation coefficient.

Table 3.

Comparison of macular thickness differences between Fourier domain OCT and Stratus OCT in normal eyes and diseased eyes

ETDRS^* area	Normal eyes	Diseased Eye	p-value
Fovea (500 μm radius)	36.14±22.08	48.08±78.84	0.46
Inner ring (1.5 mm radius)
Superior	21.83±8.74	34.69±44.62	0.16
Temporal	22.91±18.41	41.35±44.35	0.06
Inferior	19.31±6.75	29.65±60.31	0.39
Nasal	30.37±17.88	46.04±62.63	0.23
Outer ring (3.0 mm radius)
Superior	14.71±9.11	22.08±33.66	0.29
Temporal	12.14±22.16	29.54±46.15	0.09
Inferior	16.97±13.17	22.81±49.15	0.56
Nasal	24.26±18.70	30.12±32.92	0.28
Total macular volume (mm³)	0.50±0.20	0.44±1.31	0.06

^*Early Treatment Diabetic Retinopathy Study.

Table 4.

Comparison of macular thickness differences between Fourier domain OCT and Stratus OCT for DME and wet AMD compared with normal eyes

ETDRS^* area	Normal eyes	DME^†	p-value	Wet AMD^‡	p-value
Fovea (500 μm radius)	36.14±22.08	55.33±68.42	0.08	38.18±93.80	0.90
Inner ring (1.5 mm radius)
Superior	21.83±8.74	31.80±24.78	0.07	38.64±63.94	0.07
Temporal	22.91±18.41	43.33±49.99	0.06	38.64±37.46	0.13
Inferior	19.31±6.75	26.87±53.33	0.41	33.45±71.30	0.07
Nasal	30.37±17.88	35.73±40.63	0.51	60.09±84.38	0.24
Outer ring (3.0 mm radius)
Superior	14.71±9.11	19.47±30.84	0.40	18.08±33.66	0.56
Temporal	12.14±22.16	32.60±59.44	0.08	19.54±46.15	0.48
Inferior	16.97±13.17	25.07±51.52	0.39	19.73±48.02	0.76
Nasal	24.26±18.70	25.87±30.08	0.82	33.64±36.11	0.36
Total macular volume (mm³)	0.50±0.20	0.88±0.83	0.06	0.87±1.04	0.06

^*Early Treatment Diabetic Retinopathy Study

^†Diabetic macular edema.

^‡Age-related macular degeneration.

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