Jae Yeon Seok; Sang Kyum Kim; Young Nyun Park

doi:10.4166/kjg.2009.54.1.1

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Seok, Kim, and Park: Multicentric Hepatocellular Carcinomas and Multiple Dysplastic Nodules − Spectrum of Nodular Lesions in Hepatitis B-viral Cirrhotic Liver −

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Korean J Gastroenterol 2009;54(1):1-4.

Published online: 21 February 2009

DOI: https://doi.org/10.4166/kjg.2009.54.1.1

Multicentric Hepatocellular Carcinomas and Multiple Dysplastic Nodules − Spectrum of Nodular Lesions in Hepatitis B-viral Cirrhotic Liver −

Jae Yeon Seok, M.D., Sang Kyum Kim, M.D.^∗, Young Nyun Park, M.D., Ph.D.^∗,

Department of Pathology, Ajou University College of Medicine, Suwon, Korea

^∗Department of Pathology, Yonsei University College of Medicine and Yonsei Liver Cancer Special Clinic, Seoul, Korea

Correspondence to: Young Nyun Park, M.D. Department of Pathology, Yonsei University College of Medicine, 134, Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea Tel: +82-2-2228-1768, Fax: +82-2-362-0860 E-mail: young0608@yuhs.ac

REFERENCES

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Fig. 1.

Gross findings of explant-ed liver. The serial cut surfaces of the liver showed multiple hepatocellular carcinomas (HCC1-3), early hepatocellular carcinomas (eHCC1-7), high-grade dysplastic nodules (DNHG1-8), low-grade dysplastic nodules (DNLG), and large regenerative nodules (LRN1-2) in the background of B viral and alcoholic macronodular cirrhosis.

Fig. 2.

Hepatocellular carcinoma and high-grade dysplastic nodule. (A) A 2 cm sized hepatocellular carcinoma (HCC 2 in Fig. 1B, arrow heads) and a 1.5 cm sized high-grade dysplastic nodule (DNHG3 in Fig. 1B) are found grossly. (B) Microscopic finding of hepatocellular carcinoma showed moderate differentiation (H-E, ×100). (C, D) Dysplatic nodule, high grade (arrows) showed increased cellularity compared to surrounding cirrhotic nodules and small liver cell change (C: H-E, ×20; D: H-E, ×100).

Fig. 3.

Early hepatocellular carcinoma. (A) A 2 cm sized and brown colored nodule (arrows) (eHCC1 in Fig. 1A) was noted in the cirrhotic liver. (B) On scan power, nodular lesions (arrows) show cellularity increased more than two times compared to that of cirrhotic nodule, and it is sur-rounded by fibrous septa of background cirrhosis (H-E, scan power). (C) Well differentiated hepatocellular carcinoma showed nor-motrabecular pattern, several un-paired arteries without accompanying bile duct and stromal invasion of tumor cells (arrows) (C: H-E, ×20; D: H-E, ×100).

Fig. 4.

Low-grade dysplastic nodule. (A) A 1 cm sized, large nodule (DNLG in Fig. 1A) (arrows) is noted under the Glisson's ca-pule grossly. This nodule was dis-tinguished from the adjacent cirrhotic nodules due to its size, col-or, and bulging out texture. (B-D) The low grade dysplastic nodule (arrows) showed mild dysplasia and a slightly increased cellularity compared to surrounding cirrhotic nodules. Several portal tracts were found in the dysplastic nodule (B, H-E, scan power; C: H-E, ×20; D: H-E, ×100).

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