Clinicopathological Characteristics and Prognostic Factors of Papillary Carcinoma of the Breast

Seho Park; Joo-Hee Kim; Seokmo Kim; Byeong-Woo Park; Kyong Sik Lee

doi:10.4048/jbc.2008.11.2.77

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Park, Kim, Kim, Park, and Lee: Clinicopathological Characteristics and Prognostic Factors of Papillary Carcinoma of the Breast

Original Article

Journal of Breast Cancer

Journal of Breast Cancer 2008; 11(2): 77-82.

Published online: 30 June 2008

DOI: https://doi.org/10.4048/jbc.2008.11.2.77

Clinicopathological Characteristics and Prognostic Factors of Papillary Carcinoma of the Breast

Seho Park^*, Joo-Hee Kim^*, Seokmo Kim, Byeong-Woo Park, Kyong Sik Lee¹

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

¹Department of Surgery, Pochon CHA University College of Medicine, Seongnam, Korea.

bwpark@yuhs.ac

Equal contributor:

*These authors contributed equally to the work presented here.

Received 17 January 2008 Accepted 2 May 2008

Abstract

Purpose

Papillary carcinoma of the breast is a rare disease and accounts for 1-2% of all breast cancers. Because of its rarity, there have been no reports regarding prognostic factors of papillary carcinoma of the breast. The aim of this study was to review the clinicopathological factors and treatment modalities of papillary carcinoma of the breast and to evaluate the relationship between these factors and survival rates.

Methods

We retrospectively analyzed 31 patients diagnosed with papillary carcinoma of the breast from January 1986 to December 2005.

Results

The mean age of the patients was 53.5 yr. The most common symptom was a palpable mass (n=27). The mean size of a tumor was 3.5 cm and 41.9% of the patients were categorized as T2. Eighteen patients had node negative breast cancer. According to the TNM stage, there were 5, 5, 16 and 2 patients with stage 0, I, II and III disease, respectively. Expression of estrogen receptor and progesterone receptor were positive in 80.8% and 69.2% of the patients, respectively. Twenty-three patients underwent mastectomy and eight patients underwent breast-conserving surgery. Fourteen patients received chemotherapy, 20 patients received hormone therapy, and 10 patients received radiotherapy. The 10-yr disease-free survival rate and 10-yr overall survival rate were 74.9% and 86.1%, respectively. Axillary lymph node negative and an age under 50 yr were statistically significant factors in 5-yr disease-free survival and in 5-yr overall survival, respectively.

Conclusion

Papillary carcinoma of the breast showed a favorable outcome. Lymph node status and age were statistically significant factors for survival rates. The tumor size and stage had a relation with the survival rate, although the relation was not statistically significant.

Keywords: Breast, Papillary carcinoma, Prognosis

Figures and Tables

Fig 1

Microscopic findings of papillary carcinoma of the breast. Papillary carcinoma demonstrates a monotonous cellular proliferation with papillary architecture and nuclear hyperchromasia. The inset is a higher power of the carcinoma and reveals cellular pleomorphism and numerous mitoses (H&E stain, ×100).

Fig 2

10-yr disease-free survival curve.

Fig 3

10-yr overall survival curve.

Table 1

Clinical characteristics of patients of papillary carcinoma of the breast

Table 2

Pathological characteristics of tumor in papillary carcinoma of the breast

ER=estrogen receptor; PR=progesterone receptor; diff=differentiated.

Table 3

Treatment modality in papillary carcinoma of the breast

BCS=breast conserving surgery.

Table 4

5-yr disease-free survival and 5-yr overall survival according to the clinicopathological factors and treatment modalities in papillary carcinoma of the breast

5-yr DFS=5-year disease-free survival; 5-yr OS=5-year overall survival; NS=not significant; BCS=breast conserving surgery.

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