Role of Dendritic Cells in the Airway Mucosa

Seok Hyun Cho

doi:10.7599/hmr.2013.33.1.45

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Cho: Role of Dendritic Cells in the Airway Mucosa

Review Article

Hanyang Medical Reviews

Hanyang Medical Reviews 2013; 33(1): 45-51.

Published online: 27 February 2013

DOI: https://doi.org/10.7599/hmr.2013.33.1.45

Role of Dendritic Cells in the Airway Mucosa

Seok Hyun Cho

Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to: Seok Hyun Cho. Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea. Tel:+82-2-2290-8583, Fax: +82-2-2293-3335, shcho@hanyang.ac.kr

Received 2 November 2012 Revised 5 January 2013 Accepted 11 January 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dendritic cells (DC) are located at the environment-host interface and are continuously exposed to a vast array of foreign proteins and pathogens. The major role of DC is to sample environmental antigens and then to migrate to regional lymph nodes where they present processed antigenic peptides to T cells. Therefore, DC can polarize naïve T cells into either Th1 or Th2 effector cells and have a central role in coordinating the balance between immunity and tolerance to inhaled antigens. DC studies can be difficult to perform, because there is no specific cell surface marker for DC. Furthermore, they are a minor population in blood and tissue, and show heterogeneity (many subtypes) and remarkable functional plasticity (immature and mature types). Many DC experiments performed in mouse models may be very different in human disease. There are still unknown questions regarding origin, function, and the molecular events governing their characteristic features. Therefore, better understanding of human DC biology will allow us in the future to use DC as a new therapeutic target for refractory airway diseases including asthma, allergic rhinitis and chronic rhinosinusitis with polyposis.

Keywords: Dendritic Cells, Lung Diseases, Hypersensitivity, Humans

Figures and Tables

Table 1

Heterogeneity and phenotypes of human dendritic cells

mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cell; Lin, lineage; BDCA, blood dendritic cell antigen; ILT, immunoglobulin-like transcript.

References

1. Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med. 1993. 177:397–407.

2. So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006. 103:3740–3745.

3. Day SB, Ledford JR, Zhou P, Lewkowich IP, Page K. German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment. J Innate Immun. 2012. 4:100–110.

4. Lee HC, Ziegler SF. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NF-kappaB. Proc Natl Acad Sci U S A. 2007. 104:914–919.

5. Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol. 1998. 160:1224–1232.

6. Cao W. Molecular characterization of human plasmacytoid dendritic cells. J Clin Immunol. 2009. 29:257–264.

7. Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med. 2002. 196:1645–1651.

8. Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, et al. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol. 1996. 157:607–616.

9. Tunon-De-Lara JM, Redington AE, Bradding P, Church MK, Hartley JA, Semper AE, et al. Dendritic cells in normal and asthmatic airways: expression of the alpha subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI-alpha). Clin Exp Allergy. 1996. 26:648–655.

10. Beaulieu S, Robbiani DF, Du X, Rodrigues E, Ignatius R, Wei Y, et al. Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. J Immunol. 2002. 169:2925–2936.

11. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, et al. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007. 179:5897–5906.

12. Fainaru O, Shseyov D, Hantisteanu S, Groner Y. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci U S A. 2005. 102:10598–10603.

13. Brandenburg AH, Kleinjan A, van Het Land B, Moll HA, Timmerman HH, de Swart RL, et al. Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol. 2000. 62:267–277.

14. Hattori H, Okano M, Yoshino T, Akagi T, Nakayama E, Saito C, et al. Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosa of patients with perennial allergic rhinitis. Clin Exp Allergy. 2001. 31:1242–1249.

15. Hattori H, Okano M, Kariya S, Nishizaki K, Satoskar AR. Signals through CD40 play a critical role in the pathophysiology of Schistosoma mansoni egg antigen--induced allergic rhinitis in mice. Am J Rhinol. 2006. 20:165–169.

16. Julia V, Hessel EM, Malherbe L, Glaichenhaus N, O'Garra A, Coffman RL. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity. 2002. 16:271–283.

17. Constant SL, Brogdon JL, Piggott DA, Herrick CA, Visintin I, Ruddle NH, et al. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J Clin Invest. 2002. 110:1441–1448.

18. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003. 3:133–146.

19. Schmidt SV, Nino-Castro AC, Schultze JL. Regulatory dendritic cells: there is more than just immune activation. Front Immunol. 2012. 3:274.

20. Stumbles PA, Thomas JA, Pimm CL, Lee PT, Venaille TJ, Proksch S, et al. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med. 1998. 188:2019–2031.

21. Scott CL, Aumeunier AM, Mowat AM. Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol. 2011. 32:412–419.

22. Lutz MB. Therapeutic potential of semi-mature dendritic cells for tolerance induction. Front Immunol. 2012. 3:123.

23. Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, et al. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut. 2009. 58:1481–1489.

24. Samsom JN, van der Marel AP, van Berkel LA, van Helvoort JM, Simons-Oosterhuis Y, Jansen W, et al. Secretory leukoprotease inhibitor in mucosal lymph node dendritic cells regulates the threshold for mucosal tolerance. J Immunol. 2007. 179:6588–6595.

25. van der Marel AP, Samsom JN, Greuter M, van Berkel LA, O'Toole T, Kraal G, et al. Blockade of IDO inhibits nasal tolerance induction. J Immunol. 2007. 179:894–900.

26. Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes PJ, et al. Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J Allergy Clin Immunol. 2009. 123:239–248.

27. Kalinski P. Regulation of immune responses by prostaglandin E2. J Immunol. 2012. 188:21–28.

28. Sato K, Fujita S. Dendritic cells: nature and classification. Allergol Int. 2007. 56:183–191.

29. Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science. 1998. 282:480–483.

30. Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, et al. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med. 2007. 204:2759–2769.

31. Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S. Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol. 2001. 166:2961–2969.

32. Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med. 1999. 5:919–923.

33. Gill MA, Bajwa G, George TA, Dong CC, Dougherty II, Jiang N, et al. Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol. 2010. 184:5999–6006.

34. Hartmann E, Graefe H, Hopert A, Pries R, Rothenfusser S, Poeck H, et al. Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium. Clin Vaccine Immunol. 2006. 13:1278–1286.

35. Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med. 1996. 184:2417–2422.

36. Tazi A, Bouchonnet F, Grandsaigne M, Boumsell L, Hance AJ, Soler P. Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J Clin Invest. 1993. 91:566–576.

37. Sung SS, Fu SM, Rose CE Jr, Gaskin F, Ju ST, Beaty SR. A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol. 2006. 176:2161–2172.

38. Prescott SL, Macaubas C, Holt BJ, Smallacombe TB, Loh R, Sly PD, et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol. 1998. 160:4730–4737.

39. van Benten IJ, van Drunen CM, Koopman LP, KleinJan A, van Middelkoop BC, de Waal L, et al. RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 response. J Med Virol. 2003. 71:290–297.

40. Jahnsen FL, Moloney ED, Hogan T, Upham JW, Burke CM, Holt PG. Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax. 2001. 56:823–826.

41. Bratke K, Lommatzsch M, Julius P, Kuepper M, Kleine HD, Luttmann W, et al. Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge. Thorax. 2007. 62:168–175.

42. Masuyama K, Till SJ, Jacobson MR, Kamil A, Cameron L, Juliusson S, et al. Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: effect of topical corticosteroids. J Allergy Clin Immunol. 1998. 102:610–617.

43. Cameron L, Hamid Q, Wright E, Nakamura Y, Christodoulopoulos P, Muro S, et al. Local synthesis of epsilon germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure. J Allergy Clin Immunol. 2000. 106:46–52.

44. KleinJan A, Willart M, van Rijt LS, Braunstahl GJ, Leman K, Jung S, et al. An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol. 2006. 118:1117–1125.

45. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature. 1992. 360:258–261.

46. Lee AW, Truong T, Bickham K, Fonteneau JF, Larsson M, Da Silva I, et al. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunotherapy. Vaccine. 2002. 20:Suppl 4. A8–A22.

47. Ishida Y, Nakamura F, Kanzato H, Sawada D, Hirata H, Nishimura A, et al. Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. J Dairy Sci. 2005. 88:527–533.

48. Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011. 364:1005–1015.

49. Hegmans JP, Hemmes A, Aerts JG, Hoogsteden HC, Lambrecht BN. Immunotherapy of murine malignant mesothelioma using tumor lysate-pulsed dendritic cells. Am J Respir Crit Care Med. 2005. 171:1168–1177.

50. Worgall S, Kikuchi T, Singh R, Martushova K, Lande L, Crystal RG. Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells. Infect Immun. 2001. 69:4521–4527.

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