In this article, the annual reports of the Korean Nosocomial Infections Surveillance System (KONIS) were referred for the description of the current status of healthcare-associated infections (HAI) in Korea. KONIS has been established with the cooperation of the Korean Society for Nosocomial Infection Control and the Korea Centers for Disease Control and Prevention since 2006. The KONIS surveillance of healthcare-associated infections at intensive care units (ICU) and surgical site infections was performed by 116 ICUs of 63 hospitals in 2009. According to the 2010 report of KONIS, the infection rate per 1,000 patient-days in ICU is 7.65. The device-associated infection rates of bloodstream infection, urinary tract infection, and pneumonia are 3.27, 4.80, and 1.86, respectively. Surgical site infection (SSI) rates of gastric surgery, colon surgery, rectal surgery, craniotomy, ventricular shunt and spinal fusion are 3.3%, 4.7%, 5.8%, 3.6%, 5.1% and 3.9%, respectively. The SSI rates of gastrectomy and knee prosthesis are over 90 percentiles of the data of National Healthcare Safety Network, USA. In conclusion, the current healthcare-associated infection rates are higher than those of other developed countries. Through the harmonized communication of various specialists such as infectious diseases physicians, clinical microbiologists, and infection control nurses, the HAI should be monitored and prevented.