Journal List > J Korean Assoc Oral Maxillofac Surg > v.36(1) > 1032418

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Lee, Jeong, Choi, Lee, Jang, and Rim: Effect of bovine bone (Bio-Oss®) and platelet rich plasma, platelet poor plasma on sinus bone graft in rabbit
Original Article

J Korean Assoc Oral Maxillofac Surg 2010;36(1):39-42.

Published online: 15 January 2010

DOI: https://doi.org/10.5125/jkaoms.2010.36.1.39

Effect of bovine bone (Bio-Oss®) and platelet rich plasma, platelet poor plasma on sinus bone graft in rabbit

Tai-Hyung Lee, You-Min Jeong, Yong-Kun Choi1, Eui-Seok Lee, Hyon-Seok Jang, Jae-Suk Rim

Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University

1EB Dental Clinic

Jae-Suk Rim Guro 2-dong, Guro-gu, Seoul, 152-703, Korea Department of OMFS, Korea University Guro Hospital Tel : +82-2-2626-3264 E-Mail : jaesrim@korea.ac.kr

Received 26 October 2009       Revised 8 December 2009       Accepted 6 January 2010

Copyright © 2010 Korean Association of Oral and Maxillofacial Surgeons

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft.
Bio-Oss® has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-β, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP.
Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-Oss® and PRP, and Bio-Oss® and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis.
As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.

Keywords: Maxillary sinus, Bio-Oss®, Platelet-rich plasma (PRP), Platelet poor plasma (PPP)

References

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Fig. 1.
A. Bio-Oss® + PRP, 4 weeks. B. Bio-Oss® + PRP, 8 weeks. C. Bio-Oss® + PRP, 12 weeks. PRP, Platelet rich plasma.
jkaoms-36-39f1.tif
Fig. 2.
A. Bio-Oss® + PPP, 4 weeks. B. Bio-Oss® + PPP, 8 weeks. C. Bio-Oss® + PPP, 12 weeks. PPP, Platelet poor plasma.
jkaoms-36-39f2.tif
Table 1.
Newly formed tissue formation (Mean value, %) at 4, 8, 12 weeks after surgery (SD) & P-value (α =0.05).
Time RPR PPP P-value
4 weeks 123.64 (54.40) 79.09 (60.99) 0.040
8 weeks 124.12 (56.12) 153.48 (100.30) 0.078
12 weeks 150.67 (60.78) 226.31 (86.73) 0.040

PRP : Bio-Oss

� + PRP PPP : Bio-Oss

� + PPP PRP, Platelet rich plasma; PPP, Platelet poor plasma.

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