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Yoo, Chang, Park, Seo, Lee, and Lee: Clinical Evaluation of Alpha-Acetyldigoxin in Patients with Congestive Heart Failure
Original Article
Korean Circulation Journal

Korean Circulation Journal 1975; 5(1): 31-35.

Published online: 30 June 1975

DOI: https://doi.org/10.4070/kcj.1975.5.1.31

Clinical Evaluation of Alpha-Acetyldigoxin in Patients with Congestive Heart Failure

Se Hwa Yoo, M.D., Rin Chang, M.D., Young Bae Park, M.D., Jungdon Seo, M.D., Young Woo Lee, M.D., Sung Ho Lee, M.D.

Copyright © 1975 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The results of alpha-acetyldigoxin(Dioxanin®) administration in 21 patients with congestive heart failure were as follows. Alpha-acetyldigoxin is a new oral preparation of cardiac glycoside derived from lanatosid C.
1. For rapid digitalization in 2-3 days, the initial dose was 1.2 to 2.6mg (average 1.96mg). For medium-fast digitalization in 4 days, the loading dose was 2.0 to 3.2mg (average 2.7mg). For slow digitalization 0.1 to 0.4mg was required for 5 to 6 days without loading dose.
The maintenance dose was 0.1 to 0.4mg (average 0.33mg) daily.
2. The therapeutic effect of acetyldigoxin was excellent in 15 cases (71%), good in 4 cases (20%) and stationary in 2 cases (9%).
3. Side effects were observed in 2 cases with usual dosage regimen. One accidental case who took single dose of 4mg(20 tablests) developed supraventricular tachycardia with varying degree of atrioventricular block, ventricular bigeminy and premature beat but recovered completely after 6 days.

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