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Lee, Lee, Jang, Lee, and Um: Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing
Original Article

Journal of the Korean Orthopaedic Association 2002; 37(3): 411-415.

Published online: 4 January 2018

DOI: https://doi.org/10.4055/jkoa.2002.37.3.411

Changes of Serum Alkaline Phosphatase and Osteocalcin during Fracture Healing

Ho Seung Lee, Choon Sung Lee, Jae Suk Jang, Jae Dam Lee, Sung Moon Um

Department of Orthopaedic Surgery, College of Medicine, Ulsan University, Seoul, Korea.

Department of Biochemistry, College of Medicine, Ulsan University, Seoul, Korea.

Department of Orthopaedic Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.

hosng@amc.seoul.kr

Copyright © 2002 The Korean Orthopaedic Association

Abstract

Purpose

To investigate changes of serum osteoblastic marker during fracture healing.

Materials and Methods

The study included 22 patients with fresh fractures. Serum alkaline phosphatase (ALP), bone specific alkaline phosphatase and osteocalcin were analyzed on the first day and 1, 2, 4 and 8 weeks after injury. The bone specific-ALP was quantified by electrophoresis. Osteocalcin was quantified by enzyme linked immunosorbent assay (ELISA).

Results

One, 2, 4 and 8 weeks after injury, mean values of serum ALP increased 1.26, 1.45, 1.63, and 1.2 times that on the first day after injury, respectively. Similarly, during the same period, bone specific ALP increased 1.38, 1.33, 1.73 and 1.25 times, and serum osteocalcins increased 1.32, 1.2, 1.64 and 2.09 times.

Conclusion

Serum ALP increased during the early soft callus phase. However, serum osteocalcins increased during the late hard callus phase. Serum alkaline phosphatase and osteocalcin warrant further study as useful prognostic indicators of fracture healing.

Keywords: Fracture healing, Osteoblastic marker, Alkaline-phosphatase, Osteocalcin

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