Journal List > Tuberc Respir Dis > v.48(4) > 1061792

Kang, Park, Jee, Choi, Kim, Park, and Choi: The effect of surfactant therapy for acute lung injury induced by intratracheal endotoxin instillation in rats examination of the lung

Abstract

BACKGROUND: Acute lung injury is an hypoxic respiratory failure resulting from damage to the alveolar-capillary membrane, which can be developed by a variety of systemic inflammatory diseases. In this study the therapeutic effects of intra-tracheal pulmonary surfactant instillation was evaluated in the intratracheal endotoxin induced acute lung injury model of a rat. METHODS: 20 Twenty Sprague-Dawley rats were divided into 4 groups, and normal saline (2 ml/kg, for group 1) or LPS (5 mg/kg, for group 2, 3, and 4) was instilled into the trachea respectively. Either normal saline (2 ml/kg, for group 1

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