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Yoldas, Ozgocmen, Yildizhan, Yigiter, Ulvi, and Ardicoglu: Auditory P300 Event-Related Potentials in Fibromyalgia Patients
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2003; 44(1): 89-93.

Published online: 29 March 2009

DOI: https://doi.org/10.3349/ymj.2003.44.1.89

Auditory P300 Event-Related Potentials in Fibromyalgia Patients

Tahir Yoldas1, Salih Ozgocmen2, Hulya Yildizhan2, Remzi Yigiter1, Hizir Ulvi1, Ozge Ardicoglu2

1Department of Neurology, Division of Rheumatology, Firat University, Faculty of Medicine, 23119 Elazig, Turkey.

2Department of Physical Medicine and Rehabilitation, , Division of Rheumatology, Firat University, Faculty of Medicine, 23119 Elazig, Turkey.

Reprint address: requests to Dr. Tahir Yoldas, Firat University, Tip Fakultesi, Noroloji Anabilim Dali, 23119, Elazig, Turkey. Tel: 90 424 233 35 55, Fax: 90 424 237 73 11, sozgocmen@hotmail.com

Received 18 January 2002       Accepted 5 August 2002

Copyright © 2003 The Yonsei University College of Medicine

Abstract

This study assessed the cognitive brain function measured by the cognitive P300 auditory event-related potentials (ERPs) in female fibromyalgia (FM) patients and compared the results with those from healthy age and education-matched controls. The relationship of the P300 potentials to the pain threshold of patients was also investigated.
The P300 component of the auditory ERPs were studied in 11 female FM patients and 10 age and education-matched healthy controls. None of the patients were taking antidepressants such as amitriptyline or serotonin-reuptake inhibitors.
The P300 latencies of the patients were not significantly different whereas the N2P3 amplitudes were significantly lower than the controls. The P300 latencies in the patients negatively correlated with the total myalgic scores (TMS) (r=-0.73) and the control point scores (CPS) (r=-0.85). On the other hand, the P300 amplitudes showed a significant correlation with the TMS (r=0.61) and the CPS (r=0.60). There was no significant correlation between the anxiety and depression scores with the P300 latency or amplitudes.
These results showed cognitive impairment, which was mainly expressed by the lower N2P3 amplitudes in patients with FM, and its clinical relevance requires further research.

Keywords: Fibromyalgia, auditory event-related potentials, P300

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