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Abstract
A 27-year-old female presented with repeated seizures. As the left frontal lobe volume was enlarged in comparison with the right frontal lobe, hemimegalencephaly was suggested. Abnormal white matter fiber tracts running from the left frontal lobe to the fornix and hippocampus were found on diffusion tensor imaging (DTI). We performed quantitative measurements of brain volume and confirmed hemimegalencephaly. DTI and MRI-based volumetry techniques
References
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Fig. 1.
A 27-year-old female with feature of hemimegalencephaly on conventional MRI (A-D), DTI (E), and MR volumetry (F). Axial T1-weighted (A) and T2 fluid-attenuated inversion recovery (B) images show asymmetrically broadened gyri of the left frontal lobe with blurring of gray-white matter differentiation. Axial T1-weighted (C) and coronal T2-weighted (D) images demonstrate asymmetric thickened left fornix, which is iso-signal intensity to white matter and mildly compressing the frontal horn of the left lateral ventricle. Aberrant and asymmetric white matter fiber tracts running from the left frontal lobe to the fornix and hippocampus are observed on DTI (E). For MR volumetry, Destrieux atlas based automatic parcellation of cortical surface is overlaied on T1-weighted image (F). DTI = diffusion tensor imaging
Table 1.
Summary of Cortical Volume and White Matter Volume in the Frontal Lobe of Both Hemisphere
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