Translation: MicroRNA Signatures as Diagnostic and Therapeutic Targets*

Scott A. Waldman; Andre Terzic

doi:10.3343/lmo.2011.1.1.1

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Waldman and Terzic: Translation: MicroRNA Signatures as Diagnostic and Therapeutic Targets*

Translation

Clinical Chemistry

Laboratory Medicine Online

Laboratory Medicine Online 2011; 1(1): 1-2.

Published online: 1 January 2011

DOI: https://doi.org/10.3343/lmo.2011.1.1.1

Translation: MicroRNA Signatures as Diagnostic and Therapeutic Targets^*

Scott A. Waldman¹, Andre Terzic²

¹Departments of Pharmacology and Experimental Therapeutics and Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

²Departments of Medicine, Molecular Pharmacology & Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, MN, USA.

Translator: Kwon Kye Chul. Department of Laboratory Medicine, College of Medicine, Chungnam National University, Chungnam, Korea. (kckwon@cnu.ac.kr). This article is translated from an English language article, originally published in Clinical Chemistry under agreement between the publishers of Laboratory Medicine Online and Clinical Chemistry. Acknowledgement and other information that is not directly related to the content of the article has not been translated, and thus omitted in this article. References are listed as they were in the original work. Original copyright © 2008 American Association for Clinical Chemistry, Inc.

Received 8 October 2010 Revised 8 October 2010 Accepted 12 October 2010

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figures and Tables

Fig. 1

Biogenesis of microRNA and microRNA-mediated gene regulation in animal cells.

Notes

This article is available from http://www.labmedonline.org

References

1. Fabbri M, Croce CM, Calin GA. MicroRNAs. Cancer J. 2008. 14:1–6.

2. Waldman SA, Terzic A. Translating microRNA discovery into clinical biomarkers in cancer. JAMA. 2007. 297:1923–1925.

3. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, et al. MicroRNA expression profile associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA. 2008. 299:425–436.

4. Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008. 18:350–359.

5. Waldman SA, Terzic MR, Terzic A. Molecular medicine hones therapeutic arts to science. Clin Pharmacol Ther. 2007. 82:343–347.

6. Chen C. MicroRNAs as oncogenes and tumor suppressors. N Engl J Med. 2005. 353:1768–1771.

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