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Lee, Chung, and Kim: Subfoveal Choroidal Thickness in Fellow Eyes of Patients with Central Serous Chorioretinopathy
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(7): 982-987.

Published online: 13 July 2012

DOI: https://doi.org/10.3341/jkos.2012.53.7.982

Subfoveal Choroidal Thickness in Fellow Eyes of Patients with Central Serous Chorioretinopathy

Seung Hyen Lee, MD, Hyewon Chung, MD, PhD, Hyung Chan Kim, MD, PhD

Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Address reprint requests to Hyung Chan Kim, MD, PhD. Department of Ophthalmology, Konkuk University Medical Center, #120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-729, Korea. Tel: 82-2-2030-8180, Fax: 82-2-2030-5273, eyekim@kuh.ac.kr

Received 21 November 2011       Accepted 25 May 2012

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To determine the relationship between subfoveal choroidal thickness of fellow eyes and choroidal vascular hyperpermeability in unilateral central serous chorioretinopathy (CSC).

Methods

Thirty patients with unilateral CSC and 28 normal subjects underwent enhanced depth imaging spectral-domain optical coherence tomography to evaluate bilateral subfoveal choroidal thickness. The subfoveal choroidal thickness was measured from the outer RPE border to the inner sclera border. Choroidal vascular hyperpermeability was visualized with indocyanine green angiography (ICGA) and analyzed.

Results

The mean subfoveal choroidal thickness in the affected eyes (439.6 ± 136.5 µm) was significantly thicker than that in fellow eyes (340.0 ± 103.3 µm, p = 0.002), and both showed statistically significant difference compared with normal subjects (266.5 ± 111.5 µm, p < 0.001, p = 0.019). The subfoveal choroidal thickness of fellow eyes with choroidal vascular hyperpermeability was 370.0 ± 176.5 µm, which differed significantly (p = 0.037) from the choroid without choroidal vascular hyperpermeability. The choroidal thickness of acute CSC was 441.6 ± 118.6 µm, and that of chronic CSC was 454 ± 166.5 µm, a difference that was not statistically significant (p = 0.676).

Conclusions

The subfoveal choroid with hyperpermeability was thicker than that without hyperpermeability on ICGA in the fellow eyes of patients with unilateral CSC. Enhanced depth imaging spectral-domain optical coherence tomography can indirectly evaluate the effects of choroidal hyperpermeability by noninvasively measuring the choroidal thickness.

Keywords: Central serous chorioretinopathy, Choroidal thickness, Choroidal vascular hyperpermeability, Enhanced depth imaging optical coherence tomography, Fellow eye

Figures and Tables

Figure 1
Representative case of a 43-year old patient with unilateral CSC. (A, B) Fundus photograph at the first examination shows serous retinal detachment of the left eye. (C, D) Juxtafoveal leaking point is seen on FA of the left eye. (E) Choroidal hyperpermeability is observed on ICGA in asymptomatic fellow eye (arrowheads). (F) Choroidal hyperpermeability surrounding leaking point on FA is also observed on ICGA (arrowheads). (G) EDI-OCT of fellow eye shows that choroidal thickness of fellow eye is thicker (305 µm, arrow) than normal. (H) EDI-OCT of affected eye shows much thickened choroid with serous detachment (481 µm).
jkos-53-982-g001
Figure 2
Case of a 51-year-old woman with unilateral CSC. (A) Fundus photograph at the first examination reveals serous retinal detachment at the fovea. (B) FA shows the extrafoveal leakage with smokestack configuration. (C) Choroidal vascular hyperpermeability at the macula area is observed on ICGA (arrowheads). (D) No choroidal vascular hyperpermeability is observed on ICGA of the fellow eye. (E) Choroidal thickness by EDI-OCT of the affected eye is 413 µm. (F) Choroidal thickness of fellow eye without choroidal vascular hyperpermeability is thinner than that of the fellow eye with hyperpermeability. The thickness by EDI-OCT was 247 µm.
jkos-53-982-g002

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