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Cho, Bae, Han, Nam, and Kim: Comparison of Choroidal Thickness in Eyes with Central Serous Chorioretinopathy, Asymptomatic Fellow Eyes and Normal Eyes
Original Article
Journal of the Korean Ophthalmological Society

Journal of the Korean Ophthalmological Society 2012; 53(1): 87-93.

Published online: 16 January 2012

DOI: https://doi.org/10.3341/jkos.2012.53.1.87

Comparison of Choroidal Thickness in Eyes with Central Serous Chorioretinopathy, Asymptomatic Fellow Eyes and Normal Eyes

Joon Hee Cho, MD1, So Hyun Bae, MD1, Jae Ryong Han, MD2, Woo Ho Nam, MD1, Ha Kyoung Kim, MD, PhD1

1Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

2Department of Ophthalmology, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Address reprint requests to Ha Kyoung Kim, MD, PhD. Department of Ophthalmology, Kangnam Sacred Heart Hospital, #948-1 Daerim 1-dong, Yeongdeungpo-gu, Seoul 150-950, Korea. Tel: 82-2-829-5193, Fax: 82-2-848-4638, ophkim@hallym.or.kr

Received 19 May 2011       Accepted 28 November 2011

Copyright © 2012 The Korean Ophthalmological Society

Abstract

Purpose

To compare the choroidal thickness in central serous chorioretiopathy (CSC) patients and normal controls using spectral domain optical coherence tomography (SD-OCT).

Methods

The authors compared the choroidal thickness in eyes with CSC, fellow eyes and in normal eyes. In addition, the authors attempted to determine any correlation between choroidal thickness and other factors such as age, height of serous retinal detachment, and spherical equivalent. Choroidal thickness was measured using a perpendicular line from the outer margin of the subfoveal retinal pigment epithelium to the inner surface of the sclera.

Results

Twenty-five eyes of 25 CSC patients, 17 fellow eyes and 29 age-matched normal eyes were examined and categorized as group 1, group 2 and group 3, respectively. Subfoveal choroidal thickness was 370.64 ± 58.06 µm in group 1, 301.85 ± 47.83 µm in group 2, and 261.84 ± 48.22 µm in group 3. The choroidal thickness in group 1 was significantly greater than those in group 2 and group 3, and the choroidal thickness in group 2 was significantly greater than that in group 3 (p = 0.001, p < 0.001, p = 0.004, respectively), where the choroidal thickness showed a negative correlation with age (p = 0.015).

Conclusions

The choroidal thickness was greater in eyes with CSC and in their fellow eyes compared to that in normal eyes. The results suggest that CSC may be caused by choroidal vascular hyperpermeability and increased hydrostatic pressure in the choroid.

Keywords: Central serous chorioretinopathy, Choroidal thickness, Spectral domain optical coherence tomography

Figures and Tables

Figure 1
Representative images of both eyes in 40-year-old female patient with central serous chorioretinopathy. The choroid is seen in cross-section image acquired by Cirrus HD-OCT high-definition single-line raster scan mode. Perpendicular line was drawn from the outer border of the retinal pigment epithelium to the inner border of the sclera using Cirrus HD-OCT software. Subfoveal choroidal thickness was measured. Choroidal thickness was 379 µm in an eye of central serous chorioretinopathy (A) and 264 µm in an asymptomatic fellow eye (B).
jkos-53-87-g001
Figure 2
Scatter plot of subfoveal choroidal thickness and age. In eyes with central serous chorioretinopathy (left), the choroidal thickness did not correlate with patient age (Spearman's correlation test, r = 0.276, p = 0.182). In normal eyes (right), however, the choroidal thickness showed negative correlation with age (Spearman's correlation test, r = -0.449, p = 0.015).
jkos-53-87-g002
Table 1
Baseline demographic characteristics of the three groups
jkos-53-87-i001

Group 1: eyes with central serous chorioretinopathy; Group 2: asymptomatic fellow eyes of central serous chorioretinopathy; Group 3: normal eyes.

BCVA = best corrected visual acuity; log MAR = logarithm of minimal angle of resolution; SRD = serous retinal detachment.

Table 2
Comparison of subfoveal choroidal thickness in three groups
jkos-53-87-i002

Group 1: eyes with central serous chorioretinopathy; Group 2: asymptomatic fellow eyes of central serous chorioretinopathy; Group 3: normal eyes.

*Wilcoxon signed rank test, p-value of group 1 and group 2; †Mann-Whitney U-test, p-value of group 1 and group 3; ‡Mann-Whitney U-test, p-value of group 2 and group 3.

Table 3
Correlation between subfoveal choroidal thickness and spherical equivalent in three groups
jkos-53-87-i003

Group 1: eyes with central serous chorioretinopathy; Group 2: asymptomatic fellow eyes of central serous chorioretinopathy; Group 3: normal eyes.

*Spearman's correlation test.

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