Corneal Endothelial Change After Intravitreal Triamcinolone Injection

Eun Hye Ryu; Jeong-Hee Lee; Soo Young Lee; Roo Min Jun

doi:10.3341/jkos.2008.49.6.886

Journal List > J Korean Ophthalmol Soc > v.49(6) > 1008283

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Ryu, Lee, Lee, and Jun: Corneal Endothelial Change After Intravitreal Triamcinolone Injection

Original Article

J Korean Ophthalmol Soc 2008;49(6):886-890.

Published online: 8 September 2008

DOI: https://doi.org/10.3341/jkos.2008.49.6.886

Corneal Endothelial Change After Intravitreal Triamcinolone Injection

Eun Hye Ryu, M.D., Jeong-Hee Lee, M.D., Soo Young Lee, M.D., Roo Min Jun, M.D.

Department of Ophthalmology, School of Medicine, Ewha Womans University, Seoul, Korea

Address reprint requests to Roo Min Jun, M.D. Department of Ophthalmology, School of Medicine Ewha Womans University, Mokdong Hospital #911-1 Mok-dong, Yangcheon-gu, Seoul 158-710, Korea Tel: 82-2-2650-5154, Fax: 82-2-2654-4334, E-mail: jrmoph@ewha.ac.kr

13 February 2008 Accepted 9 November 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the corneal endothelial cell changes after intravitreal triamcinolone (4 mg/0.1 ml, Acedolone^Ⓡ, Kuhnil) injection.

Methods

From October 2006 to January 2007, 20 eyes of 19 patients who received intravitreal triamcinolone injection were enrolled. We analyzed the changes of the corneal endothelial cells prospectively and compared them with 11 phakic eyes (group 1) and 9 pseudophakic eyes (group 2) using specular microscopy.

Results

The mean age of the patients was 65.9±8.5 years. The preoperative cell densities were 2534.1±303.6 in group 1 and 2105.9±328.0 in group 2 ( p=0.01, Mann‐ Whitney U test). The preoperative coefficients of variation of cell area were 34.6±9.7 in group 1 and 31.6±7.5 in group 2 ( p>0.05), and the preoperative hexagonalities were 56.4±13.8 in group 1 and 66.4±20.4 in group 2 ( p>0.05). The differences between preoperative and postoperative cell densities, coefficients of the variation of cell area, and hexagonalities were not statistically significant in either group ( p>0.05).

Conclusions

There was no clinically significant change in corneal endothelial cells after intravitreal triamcinolone injection.

Keywords: Corneal endothelial cell, Triamcinolone

References

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Table 1.

Patient data

	Group A	Group B
Number of Eyes	11	9
Sex (male/female)	5 / 6	7 / 2
Mean age (years)	64.0±7.7	68.2±9.3
Past history (eyes, %)
DM	4 (36.4)	7 (77.8)
HTN	7 (63.6)	6 (66.7)
Diagnosis (eyes, %)
DMR	4 (36.4)	7 (77.8)
ARMD	5 (45.5)	1 (11.1)
BRVO	2 (18.2)	‐
Uveitis	‐	1 (11.1)

DM=diabetes mellitus; HTN=hypertension; DMR=diabetes mellitus retinopathy; ARMD=age-related macular degeneration BRVO=branched retinal vascular occlusion.

Table 2.

Changes in endothelial cell count after IVTA (intravitreal triamcinolone injection) (cells/mm² mean±SD)

Time of exam	Group A	Group B
	Endothelial cell count	Endothelial cell count
Baseline	2534.1±303.6	2105.9±328.0*
Post op 1 week	2423.0±487.1	2017.8±387.8
1 month	2376.7±400.9	2082.6±379.9
2 months	2424.1±328.4	2138.4±360.4
4 months	2466.0±346.9	2098.9±496.0

^* p<0.05 Mann-Whitney U test.

Table 3.

Change in coefficient of variation after IVTA (intravitreal triamcinolone injection) (mean±SD)

Time of exam	Group A	Group B
Time of exam	Coefficient of variation	Coefficient of variation
Baseline	34.6±9.7	31.6±7.5
Post op 1 week	33.7±7.5	31.5±8.8
1 month	28.8±6.9	27.9±4.0
2 months	29.8±7.8	27.9±8.1
4 months	33.3±7.8	28.6±8.9

Table 4.

Change in hexagonality after IVTA (intravitreal triamcinolone injection) (%, mean±SD)

Time of exam	Group A	Group B
Time of exam	hexagonality	hexagonality
Baseline	56.4±13.8	64.8±22.6
Post op 1 week	57.9±11.6	67.4±12.3
1 month	53.7±11.0	62.6±9.6
2 months	54.6±15.4	67.5±6.1
4 months	56.0±8.9	64.1±11.7

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