Journal List > Korean J Gastroenterol > v.74(3) > 1134174

Shin, Chae, Kwak, Yoon, Jeon, and Cha: Mucoepidermoid Carcinoma of the Esophagus

Abstract

Mucoepidermoid carcinoma is a malignant tumor that occurs mainly in the salivary glands of adults and children, but rarely in the esophagus. A surgical resection is the primary treatment for mucoepidermal carcinoma, and the prognosis has been reported to be poor. A 61-year-old man was diagnosed with an esophageal nodule in upper gastrointestinal endoscopy for the purpose of a medical examination without any special symptoms and an endoscopic resection was performed for an accurate diagnosis. An endoscopic mucosal resection was performed using a band ligation for a complete resection and continuous follow-up with no evidence of recurrence or metastasis. The unknown prognosis of endoscopic resection makes it necessary to follow the patient carefully.

Figures and Tables

Fig. 1

(A, B) Esophagogastroduodenoscopy showing a 6-7 mm sized esophageal nodule 31 cm from the upper incisor. The surface of the nodule was flat and the consistency was firm. (C, D) Standard endoscopic variceal ligation was used to aspirate the target lesion and apply a band around it. After removing the banding device, a separate snare was used to resect the lesion with an endoscopic mucosal resection.

kjg-74-159-g001
Fig. 2

Microscopic findings showing a mucoepidermoid carcinoma consisting of squamous cells, mucus-producing cells and intermediate cells (A, B, H&E, ×200; C, H&E, ×400). Positive reaction to mucin in the mucicarmine stain (D, mucicarmine stain, ×400).

kjg-74-159-g002

Notes

Financial support This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1720230).

Conflict of interest None.

References

1. Hagiwara N, Tajiri T, Miyashita M, et al. Biological behavior of mucoepidermoid carcinoma of the esophagus. J Nippon Med Sch. 2003; 70:401–407.
crossref
2. Ghaffarzadegan K, Malekifar Z, Haghi Z, Farahmand MJ, JafariRad M. Mucoepidermoid carcinoma of the esophagus (case report). Iran J Otorhinolaryngol. 2006; 18:79–81.
3. Koide N, Hamanaka K, Igarashi J, et al. Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: report of a case. Surg Today. 2000; 30:636–642.
crossref
4. Ozawa S, Tachimori Y, Baba H, et al. Comprehensive registry of esophageal cancer in Japan, 2004. Esophagus. 2012; 9:75–98.
crossref
5. Suzuki H, Nagayo T. Primary tumors of the esophagus other than squamous cell carcinoma--histologic classification and statistics in the surgical and autopsied materials in Japan. Int Adv Surg Oncol. 1980; 3:73–109.
6. Tekade SA, Chaudhary MS, Gawande MN, Bagri K. Correlation between mucoepidermoid carcinoma grade and AgNOR count. J Oral Sci. 2010; 52:275–279.
crossref
7. Ozawa H, Tomita T, Sakamoto K, et al. Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol. 2008; 38:414–418.
crossref
8. Rapidis AD, Givalos N, Gakiopoulou H, et al. Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol. 2007; 43:130–136.
9. Kumagai Y, Ishiguro T, Kuwabara K, et al. Primary mucoepidermoid carcinoma of the esophagus: review of the literature. Esophagus. 2014; 11:81–88.
crossref
10. Mafune K. Histochemical study of adenocarcinomatous components in carcinoma of the esophagus. Nihon Geka Gakkai Zasshi. 1988; 89:162–172.
11. Chen S, Chen Y, Yang J, et al. Primary mucoepidermoid carcinoma of the esophagus. J Thorac Oncol. 2011; 6:1426–1431.
crossref
12. Ozawa S, Ando N, Shinozawa Y, et al. Two cases of resected esophageal mucoepidermoid carcinoma. Jpn J Surg. 1989; 19:86–92.
crossref
13. Takubo K. Carcinomas other than squamous cell carcinoma and adenocarcinoma. In : Takubo K, editor. Pathology of the esophagus: an atlas and textbook. New York: Springer;2007. p. 212–225.
14. Lieberman MD, Franceschi D, Marsan B, Burt M. Esophageal carcinoma. The unusual variants. J Thorac Cardiovasc Surg. 1994; 108:1138–1146.
15. Fegelman E, Law SY, Fok M, et al. Squamous cell carcinoma of the esophagus with mucin-secreting component. Mucoepidermoid carcinoma. J Thorac Cardiovasc Surg. 1994; 107:62–67.
crossref
TOOLS
ORCID iDs

Jae Myung Cha
https://orcid.org/0000-0001-9403-230X

Similar articles