Next generation sequencing and anti-cancer therapy

Joohyuk Sohn

doi:10.5124/jkma.2019.62.2.119

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Sohn: Next generation sequencing and anti-cancer therapy

Pharmacotherapeutics

Journal of the Korean Medical Association 2019; 62(2): 119-129.

Published online: 21 February 2019

DOI: https://doi.org/10.5124/jkma.2019.62.2.119

Next generation sequencing and anti-cancer therapy

Joohyuk Sohn, MD

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author: Joohyuk Sohn. oncosohn@yuhs.ac

Received 8 February 2019 Accepted 10 February 2019

Korean Medical Association

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Over the last two decades, the systemic treatment of cancer has evolved from cytotoxic chemotherapy to targeted therapy and now immunotherapy. Next-generation sequencing (NGS) is entering clinical applications for cancer treatment through the help of more powerful computational analyses. The increasing number of targeted therapies approved by regulatory authorities (RAs) with or without biomarkers necessitates the screening of multiple biomarkers using NGS, which is now approved and reimbursed by Korean RAs for some types of malignancies. However, the clinical utility of NGS remains to be established as a prerequisite for its routine incorporation into clinical practice. Currently, the best scenario of NGS use in clinics is to enroll patients into clinical trials based on the detection of biomarkers, but this is only possible in the hospitals conducting the specific trial. The other scenario is the off-label use of a targeted drug, but this requires social consensus for future implementation. The clinical applications of NGS are expanding in terms of its platforms, from targeted sequencing to whole exome and RNA sequencing, and in terms of systemic therapy, from targeted therapy to immunotherapy. Research into tumor mutational burden and neoantigens is shedding new light on the clinical use of NGS in immunotherapy.

Keywords: Next generation sequencing, Cancer, Targeted therapy, Immunotherapy

Appendix

Appendix 1

Targeted and immunotherapeutic drugs, targets, indications, and biomarker detection tests

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ORCID iDs: Joohyuk Sohn
https://orcid.org/0000-0002-2303-2764
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