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Lee, Kim, Cho, Park, Hong, and Kim: Metastatic gestational choriocarcinoma as initial presentation of intracerebral hemorrhage: A case report
Case Report
Korean Journal of Obstetrics & Gynecology

Korean Journal of Obstetrics & Gynecology 2012; 55(5): 348-352.

Published online: 16 May 2012

DOI: https://doi.org/10.5468/KJOG.2012.55.5.348

Metastatic gestational choriocarcinoma as initial presentation of intracerebral hemorrhage: A case report

Young Jin Lee, MD1, Ari Kim, MD2, Hae Joong Cho, MD2, Seong Nam Park, MD2, Sung-Nam Hong, MD3, Heung Yeol Kim, MD1

1Department of Obstetrics and Gynecology, Kosin University College of Medicine, Busan, Korea.

2Department of Obstetrics and Gynecology, Wonkwang University College of Medicine, Iksan, Korea.

3Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Corresponding author: Heung Yeol Kim, MD, PhD. Department of Obstetrics and Gynecology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 602-702, Korea. Tel: +82-51-990-6226 Fax: +82-51-990-3300, ttochil@hanmail.net

Received 13 January 2012       Revised 14 March 2012       Accepted 12 April 2012

Copyright © 2012. Korean Society of Obstetrics and Gynecology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia, which grows rapidly and metastasizes to the lung, liver, and, less frequently, brain. This tumor is known for its association with molar pregnancy, rapid hematogenous spread to multiple organs, high human chorionic gonadotropin levels, and good response to chemotherapy. Metastases to the brain are responsible for most of the deaths from choriocarcinoma. Its prognosis is generally good when treated. We report a rare case of metastatic gestational choriocarcinoma as an initial presentation of intracerebral hemorrhage.

Keywords: Brain, Gestational choriocarcinoma, Metastasis

Figures and Tables

Fig. 1
Findings of radiology. (A) Chest computed tomography suggested of lung metastasis (unknown origin) in right upper lobe and left lung. (B) Finding of brain computed tomography indicates hemorrhagic metastasis at both occipital lobes. (C) Positron emission tomography showed multiple hypermetabolic lesions in both lung and left ileum.
kjog-55-348-g001
Fig. 2
Immunohistochemical staining for the intracerebral metastatic choriocarcinoma shows positive β-human chorionic gonadotropin level (H&E, ×100).
kjog-55-348-g002

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