Journal List > J Korean Med Assoc > v.47(10) > 1080448

Roh, Kim, and Chu: Neural Stem Cells for Neurological Disorders

Abstract

Recent progress shows that neurons suitable for transplantation can be generated from neural stem cells (NSCs) in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. In this article, we discuss how the subventricular zone of the forebrain is the most active neurogenetic area and the richest source of NSCs. This review also focuses on the nature and functional properties of NSCs of the adult mammalian brain, and we propose our views on the strategy from bench to the clinic with particular concerns and considerations.

References

1. Galli R, Gritti A, Bonfanti L, Vescovi AL. Neural stem cells: an overview. Circ Res. 2003. 92:598–608.
2. Ryder EF, Snyder EY. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J Neurobiol. 1990. 21:356–375.
crossref
3. Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartweig EA, Cepko CL. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell. 1992. 68:33–51.
crossref
4. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992. 255:1707–1710.
crossref
5. Imitola J, Park KI, Teng YD, Nisim S, lachyankar M, Snyder EY, et al. Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci. 2004. 359:823–837.
crossref
6. Snyder EY, Daley GQ, Goodell M. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res. 2004. 76:157–168.
crossref
7. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med. 2004. 10:Supp 1. S42–S50.
crossref
8. Bjorklund A, Lindvall O. Cell replacement therapies for central nervous system disorders. Nat Neurosci. 2000. 3:537–544.
crossref
9. McKay R. Stem cells in the central nervous system. Science. 1997. 276:66–71.
crossref
10. Alvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci. 2001. 2:287–293.
crossref
11. Steindler DA, Kadrie T, Fillmore H, Thomas LB. The subependymal zone: brain marrow. Prog Brain Res. 1996. 108:349–363.
12. Scheffler B, Horn M, Blumcke I, Laywell ED, Coomes D, Steindler DA, et al. Marrow-mindedness: a perspective on neuropoiesis. Trends Neurosci. 1999. 22:348–357.
crossref
13. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 2000. 405:951–955.
crossref
14. Temple S, Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Curr Opin Neurobiol. 1999. 9:135–141.
crossref
15. Arvidsson A, Collin T, Kirik D, Kokaia Z, Linvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med. 2002. 8:963–970.
crossref
16. Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Greenberg DA, et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci U S A. 2001. 98:4710–4715.
crossref
17. Kokaia Z, Lindvall O. Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol. 2003. 13:127–132.
crossref
18. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol. 2002. 52:802–813.
crossref
19. Nakatomi H, Kuriu T, Okabe S, Yamamoto S, hatano O, Nakafuku M, et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 2002. 110:429–441.
crossref
20. Jung KH, Chu K, Kim M, Jeong SW, Song YM, Roh JK, et al. Continuous cytosine-b-D-arabionofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Eur J Neurosci. 2004. 19:3219–3226.
crossref
21. Sanai N, Tramontin AD, Quinones-Hinojosa A, Barbaro NM, Gupta N, Alvarez-Buylla A, et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature. 2004. 427:740–744.
crossref
22. Rothstein JD, Snyder EY. Reality and immortality-neural stem cells for therapies. Nat Biotechnol. 2004. 22:283–285.
crossref
23. Chu K, Kim M, Jung KH, Park KI, Lee ST, Roh JK, et al. Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res. 2004. 1016:145–153.
crossref
24. Jeong SW, Chu K, Jung KH, Kim SU, Kim M, Roh JK. Intravenous human neural stem cell transplantation promotes functional recovery with experimental intracranial hemorrhage in the adult rats. Stroke. 2003. 34:2258–2263.
crossref
25. Chu K, Kim M, Jung KH, Jeon D, Lee ST, Roh JK, et al. Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. Brain Res. 2004. 1023:213–221.
crossref
26. Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Bynum L, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology. 2000. 55:565–569.
crossref
27. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Gage FH, et al. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004. 430:350–356.
crossref
28. Lang AE, Obeso JE. Challenges in Parkinsons disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 2004. 3:309–316.
crossref
29. Chu K, Kim M, Jeong SW, Kim SU, Yoon BW. Human neural stem cells can migrate, differentiate and proliferate after intravenous transplantation in the adult rats with transient forebrain ischemia. Neurosci Lett. 2003. 343:129–133.
crossref
30. Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Roh JK, et al. Celecoxib Induces Functional Recovery after Intracerebral Hemorrhage with Reduction of Brain Edema and Perihematomal Cell Death. J Cereb Blood Flow Metab. 2004. 24:926–933.
crossref
31. Jung KH, Chu K, Jeong SW, Han SY, Lee ST, Roh JK, et al. HMG-CoA reductase inhibitor, atorvastatin, ameliorates sensorimotor dysfunctions in experimental intracerebral hemorrhage. Stroke. 2004. 35:1744–1749.
crossref
32. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Martino G, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003. 422:688–694.
crossref
33. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Snyder EY, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA. 2000. 97:12846–12851.
crossref
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