Journal List > J Korean Med Assoc > v.47(10) > 1080447

Kim: Hepatic Stem Cell Transplantation in Liver Failure

Abstract

Whole or partial liver transplantation has become one of the main treatment strategies for hepatic failure. The availability of a donor liver is the single most limiting factor in liver transplantation. In cell therapy, liver cells have been used clinically to bridge patients to whole organ transplantation and/or as an alternative to whole organ transplants. The crucial property that defines a stem cell is its ability to give rise to a large family of descendants, and at least some hepatocytes do exhibit this pleuripotency. Thus hepatocyte-like cells derived from the bone marrow, embryonal stem cells, or placental sources can also be used. Stem cells of many types have been prodded and cajoled by combinations of growth factors, matrix and culture modifications to identify conditions that favor differentiation or transdifferentiation of stem/progenitor cells into hepatocytes. Additional studies are needed to determine whether hepatocyte-like cells derived from the bone marrow or other sources express the full complement of hepatic functions. If a sufficient number of differentiated hepatocytes can be produced from these stem cells, they could be useful in clinical transplantation programs.

References

1. Wong KK, De Pinho RA. Walking the telomere plank into cancer. J Natl Cancer Inst. 2003. 95:1184–1186.
crossref
2. Overturf K, al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol. 1997. 151:1273–1280.
3. Alison MR. Liver regeneration with reference to stem cells. Semin Cell Dev Biol. 2002. 13:385–387.
crossref
4. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T. Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology. 1997. 25:329–334.
crossref
5. Hooth MJ, Coleman WB, Presnell SC, Borchert KM, Grisham JW, Smith GJ. Spontaneous neoplastic transformation of WBF344 rat liver epithelial cells. Am J Pathol. 1998. 153:1913–1921.
crossref
6. Ott M, Rajvanshi P, Sokhi R, Alpini G, Aragona E, Dabeva M, et al. Differentiation-specific regulation of transgene expression in a diploid epithelial cell line derived from the normal F344 rat liver. J Pathol. 1999. 187:365–373.
crossref
7. Dabeva MD, Hwang SG, Vasa SR, Hurston E, Novikoff PM, Hixson DC, et al. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci USA. 1997. 94:7356–7361.
crossref
8. Wang X, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol. 2001. 158:571–579.
crossref
9. Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci. 2003. 100:11881–11888.
crossref
10. Jones EA, Tosh D, Wilson DI, Lindsay S, Forrester LM. Hepatic differentiation of murine embryonic stem cells. Exp Cell Res. 2002. 272:15–22.
crossref
11. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, et al. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology. 2003. 37:983–993.
crossref
12. Chinzei R, Tanaka Y, Shimizu-Saito K, Hara Y, Kakinuma S, Watanabe M, et al. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology. 2002. 36:22–29.
crossref
13. Hamilton WJ, Boyd JD, editors. Human embryology. 1964. 3rd ed. Cambridge: Heffer;240–244.
14. Arias DM, Boyer JL, editors. The liver biology, biology and pathobiology. 1994. 3rd ed. New York: Lippincott Williams & Wilkins;1501–1508.
15. Dabeva MD, Petkov PM, Sandhu J, Oren R, Laconi E, Hurston E, et al. Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation into adult rat liver. Am J Pathol. 2000. 156:2017–2031.
crossref
16. Malhi H, Irani AN, Gagandeep S, Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci. 2002. 115:2679–2688.
crossref
17. Sigal S, Gupta S, Gebhard DF Jr, Holst P, Neufeld D, Reid LM. Evidence for a terminal differentiation process in the liver. Differentiation. 1999. 59:35–42.
crossref
18. Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells. Am J Pathol. 2001. 159:1323–1334.
crossref
19. Habibullah CM. Hepatocyte transplantation: need for liver cell bank. Trop Gastroenterol. 1992. 13:129–131.
20. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri RK, et al. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology. 2003. 124:432–444.
crossref
21. Zaizman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, et al. Reversal of hyperglycemia in mice using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA. 2003. 100:7253–7258.
22. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999. 284:1168–1170.
crossref
23. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000. 31:235–240.
crossref
24. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 2002. 346:738–746.
crossref
25. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osbome L, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000. 6:1229–1234.
crossref
26. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little Evidence for developmental plasticity of adult hematopoietic Stem Cells. Science. 2002. 297:2256–2259.
crossref
27. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature. 2003. 422:897–901.
crossref
28. Newsome PN, Johannessen I, Boyle S, Dalakas E, McAulay KA, Samuel K, et al. Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology. 2003. 124:1891–1900.
crossref
29. Austin TW, Lagasse E. Hepatic regeneration from hematopoietic stem cells. Mech Dev. 2003. 120:131–135.
crossref
30. Kim DK, Fujiki Y, Fukushima T, Ema H, Shibuya A, Nakauchi H. Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells. Stem Cells. 1999. 17:286–294.
crossref
31. Tang XP, Yang X, Tan H, Ding YL, Zhang M, Wang WL. Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis. World J Gastroenterol. 2003. 9:1999–2003.
crossref
32. Strom SC, Fisher RA, Rubinstein WS, Barranger JA, Towbin RB, Reyes J, et al. Transplantation of human hepatocytes. Transplant Proc. 1997. 29:2103–2106.
crossref
33. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Posner MP, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation. 1997. 63:559–569.
crossref
34. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Strom SC, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. New Engl J Med. 1998. 338:1422–1426.
crossref
35. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Durham J, et al. Hepatocyte transplantation in acute liver failure. Liver Transpl. 2000. 6:32–40.
crossref
36. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation. 1994. 58:951–952.
crossref
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