The purpose of the Industrial Accident Compensation Insurance Act is to compensate any occupational accident of workers in a rapid and fair manner. To reduce the burden of proof of causation, there is a way to establish presumptive standards such as 'Guidelines for Work-related Diseases'. A presumptive standard defines a level of evidence sufficient to demonstrate legally a causal relationship between occupation and disease. In Korea, 24 items including physical agents, chemical agents, biological agents and some diseases are enlisted as work-related diseases.