PURPOSE: The purpose of this study was to discuss and address the state of the knowledge development and the nature of knowledge regarding fatigue. METHOD: This study analyzed the 63 fatigue related articles published from 1990 to 2001. The analysis schema was 'Alternative linkages among philosophy, theory, and method for nursing science' (Kim, 1993). RESULT: The 63 articles had been studied only within 5 types among all 96 types of linkages. Most of the articles (59 among 63 articles) had been studied within scientific realism and deductive logic. Fifty-three articles among 59 articles were the type of explanatory and predictive theory, grasping reality by the etic method on the controlled setting. CONCLUSION: This study suggests more development of knowledge regarding fatigue with various logics, especially with discovery logic such as inductive and retroductive or methods in multiple designs on various subjects under various philosophy needed for nursing practice.