Three Cases of Pertussis in Infants younger than Three Months without Immunization of DTaP

Hyung Kung Seo; Ran Hee Kim; Seong Heon Kim; Hye Young Kim; Soo Eun Park; Hee Ju Park; Seung Ju Lee; Hye Jung Kim

doi:10.7581/pard.2011.21.1.56

Journal List > Pediatr Allergy Respir Dis > v.21(1) > 1033152

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Seo, Kim, Kim, Kim, Park, Park, Lee, and Kim: Three Cases of Pertussis in Infants younger than Three Months without Immunization of DTaP

Abstract

Pediatr Allergy Respir Dis 2011;21(1):56-60.

Published online: 20 January 2011

DOI: https://doi.org/10.7581/pard.2011.21.1.56

Three Cases of Pertussis in Infants younger than Three Months without Immunization of DTaP

Hyung Kung Seo, M.D., Ran Hee Kim, M.D., Seong Heon Kim, M.D., Hye Young Kim, M.D., Soo Eun Park, M.D., Hee Ju Park, M.D., Seung Ju Lee^∗, Hye Jung Kim^†,

Department of Pediatrics, Pusan National University, Seoul, Korea

^∗School of Medicine, Busan Metropolitan City institute of Health & Environment, Seoul, Korea

^†Gyeongsangnam-Do Goverment Reserch Institute of Public Health and Environment, Seoul, Korea

책임저자: 김혜영, 부산광역시 서구 아미동 1가 부산대학교 의과대학 소아과학교실 Tel: 051)240-7298 Fax.: 051)240-7298 E-mail: ssun0@hanmail.net

Received 21 October 2010 Accepted 2 March 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pertussis is a pediatric infectious disease with one of the highest degrees of infectivity. Although pertussis may cause asymptomatic infections in children and adults with immunity, it can cause life-threatening diseases in newborn babies or infants. We report three cases of pertussis in infants ˂ 3 months of age without DTaP immunization who have received symptomatic treatment with the diagnosis of bronchiolitis from other hospitals, and subsequently correctly diagnosed and treated. The patients did not have the characteristic whooping cough, but the main symptoms were episodic cough, intermittent vomiting, and cyanosis. Based on culture results for Bordetella pertussis and PCR, pertussis was diagnosed and treated without any complications. As it is assumed that adults, adolescents, and asymptomatic patients may serve as sources of infection, immunization with Tdap vaccine is recommended to prevent dissemination of pertussis from adolescents and adults to infants, and thus maintain herd immunity.

Keywords: Pertussis, Infant, Polymerase chain reaction

References

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Fig. 1.

Detection of B. pertussis by polymerase chain reaction. (A) Lane 1, 100bp DNA ladder; Lane 2, Negative control; Lane 3, Positive control(B. pertussis); Lane 4, case 1 sample (B) Lane 1, 100bp DNA ladder; Lane 2, case 2 sample; Lane 3, Positive control; Lane 4, Negative control (C) Lane 1, 100bp DNA ladder; Lane 2, Negative control; Lane 3, Positive control; Lane 4, case 3 sample, Lane 5, case 3 sample

Table 1.

Clinical Details of One Neonate and Two Infant with Pertussis

Case	Age and sex	Signs and symptoms	Duration of cough (days)	Diagnosis at other hospitals	Leukocyte count×10³/μL (%lymphocyte)	DTaP vaccination	Laboratory test
Case	Age and sex	Signs and symptoms	Duration of cough (days)	Diagnosis at other hospitals	Leukocyte count×10³/μL (%lymphocyte)	DTaP vaccination	PCR	Culture
1	20 days (M)	paroxysmal cough vomiting, cyanosis	20	Bronchiolitis	22.45 (68.0)	–	+	–
2	78 days (M)	paroxysmal cough cyanosis	24	Bronchiolitis	17.84 (78.0)	–	+	+
3	75 days (M)	paroxysmal cough cyanosis	28	Bronchiolitis	21.05 (67.9)	–	+	–

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