Journal List > Korean J Hematol > v.44(4) > 1032845

Ko, Yang, Kim, Yun, Kim, Lee, Bae, Kim, Lee, Park, Lee, Won, Hong, Park, and Kim: A Case of Solitary Involved NK-T Cell Lymphoma on the Gallbladder

Abstract

Extranodal NK-T cell lymphoma is a subtype of non-Hodgkin's lymphoma (NHL) and this most commonly affects the nasal and paranasal cavities. Primary lymphoma of the gallbladder is extremely rare and solitary relapsed extranodal NK-T cell lymphoma of the gallbladder has not yet been reported in Korea. We experienced a case of a solitary relapsed extranodal NK-T cell lymphoma of the gallbladder. One year earlier, a 55-year-old man was diagnosed with extranodal NK-T cell lymphoma of the anus, and he underwent six cycles of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine and prednisone), and he achieved complete remission. The patient was admitted for right upper quadrant pain. Computed tomography (CT) performed on readmission revealed gallbladder wall thickening. Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed hypermetabolic lesions along the gallbladder wall. The specimen obtained at cholecystectomy revealed CD3(+) and CD56(+) lymphoma, which is characteristic of NK-T cell lymphoma.

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Fig. 1.
Dynamic abdomen-pelvic CT scans showed that the mucosal surface of gallbladder was irregularly thickened and its lamina layer was also enhanced.
kjh-44-268f1.tif
Fig. 2.
Focal hypermetabolism was observed in the upper and mid-body portion of the gallbladder on FDG-PET scan (p-SUV=9.7).
kjh-44-268f2.tif
Fig. 3.
Pathologic findings of gallbladder (A) The gallbladder was thickened diffusely and showed granular appearance. (B) An artery was infiltrated with lymphoma and destructed (H-E, ×100). And the lymphoma cells were stained strongly for (C) CD3 and (D) CD56 (Immunohistochemistry, ×200).
kjh-44-268f3.tif
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