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Chang: Pharmacological Functional Magnetic Resonance Imaging of Cloropidol on Motor Task
Original Article
Journal of the Korean Society of Magnetic Resonance in Medicine

Journal of the Korean Society of Magnetic Resonance in Medicine 2012; 16(2): 136-141.

Published online: 31 August 2012

DOI: https://doi.org/10.0000/jksmrm.2012.16.2.136

Pharmacological Functional Magnetic Resonance Imaging of Cloropidol on Motor Task

Yongmin Chang1, 2, 3

1Department of Molecular Medicine, Kyungpook National University College of Medicine, Daegu, Korea.

2Department of Medical & Biological Engineering, Kyungpook National University College of Medicine, Daegu, Korea.

3Department of Radiology, Kyungpook National University College of Medicine, Daegu, Korea.

Corresponding author: Yongmin Chang, Ph.D., Department of Molecular Medicine & Radiology, Kyungpook National University and Hospital, 50, Samduk-Dong 2ga, Chung-gu, Daegu 700-721, Korea. Tel. 82-53-420-5471, Fax. 82-53-422-2677, ychang@knu.ac.kr

Received 21 June 2012       Revised 3 August 2012       Accepted 8 August 2012

Copyright © 2012 Korean Society of Magnetic Resonance in Medicine

Abstract

Purpose

To investigate the pharmacologic modulation of motor task-dependent physiologic responses by antiplatelet agent, clopidogrel, during hand motor tasks in healthy subjects.

Materials and Methods

Ten healthy, right-handed subjects underwent three functional magnetic resonance (fMRI) sessions: one before drug administration, one after high dose drug administration and one after reaching drug steady state. For the motor task fMRI, finger flexion-extension movements were performed. Blood oxygenation level dependent (BOLD) contrast was collected for each subject using a 3.0 T VHi (GE Healthcare, Milwaukee, USA) scanner. T2*-weighted echo planar imaging was used for fMRI acquisition. The fMRI data processing and statistical analyses were carried out using SPM2.

Results

Second-level analysis revealed significant increases in the extent of activation in the contralateral motor cortex including primary motor area (M1) after drug administration. The number of activated voxels in motor cortex was 173 without drug administration and the number increased to 1049 for high dose condition and 673 for steady-state condition respectively. However, there was no significant difference in the magnitude of BOLD signal change in terms of peak T value.

Conclusion

The current results suggest that cerebral motor activity can be modulated by clopidogrel in healthy subjects and that fMRI is highly senstive to evidence such changes.

Keywords: Antiplatelet drug, Functional Magnetic resonance imaging (fMRI), Motor function

Figures and Tables

Fig. 1
Brain activation maps by right motor task before and after Clopidogrel administration. Left side of the figure corresponds to the left hemisphere.
jksmrm-16-136-g001
Table 1
Significant Regional Brain Activity in no Drug (Day 0), High Dose (Day 1), and Steady-state (Day 6) Condition
jksmrm-16-136-i001

Acknowledgements

This work was supported by the Ministry of Health & Welfare, KOREA (A092106).

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