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Abstract
Purpose
To investigate the frequency of side effects due to the use of cyclopentolate for cycloplegic refraction.
Methods
For 4 months, temperature change and adverse effects in 157 children who visited the pediatric ophthalmology clinic of a university hospital for cycloplegic refraction using cyclopentolate were observed. Topical 1% cyclopentolate was instilled 5 times at 5 minute intervals and temperature measured before and after administration using a tympanic thermometer. Side effects such as facial flushing, skin rash, and central nervous system disorders were recorded while cycloplegic refraction was performed.
Results
The mean temperature was increased 36.67 ± 0.10°C to 36.90 ± 0.09°C, but no fever exceeded 38°C. Seventeen (10.83%) patients experienced side effects including facial flushes (n = 6), temperature change (n = 5), abnormal central nervous system symptoms (n = 4), and a visible skin rash (n = 2). No patient experienced more than 1 side effect and long term adverse effects were not observed.
References
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Figure 1.
(A, B) Facial flushing after five times instillation of 0.5% cyclopentolate of 1 year old baby (A: before using, B: after using).
Table 1.
Mean temperature change after cyclopentolate cycloplegic refraction (CR) according to age
Table 2.
Symptoms of central nervous system (CNS) disorders after 1% cyclopentolate cycloplegic refraction
| Age (years) | Sex | CNS stimulatory or inhibitory symptoms |
|---|---|---|
| 7 | M | Drowsy, irritability, incorperation |
| 9 | M | Mild drowsy |
| 10 | M | Gait disturbance, illusion, delirium |
| 12 | F | Gait disturbance, illusion, delirium |
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