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Han, Bae, Chung, and Chung: The Correlations between Donor Endothelial Lenticule Thickness and Visual Prognosis in DSAEK
Original Article

J Korean Ophthalmol Soc 2007;54(7):1139-1143.

Published online: 24 August 2007

DOI: https://doi.org/10.3341/jkos.2013.54.2.210

The Correlations between Donor Endothelial Lenticule Thickness and Visual Prognosis in DSAEK

Jong Chul Han, MD, Ji Hyun Bae, MD, Tae Young Chung, MD, PhD, Eui Sang Chung, MD, PhD

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Address reprint requests to Eui Sang Chung, MD, PhD Department of Ophthalmology, Samsung Medical Center #81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea Tel: 82-2-3410-3565, Fax: 82-2-3410-0074, E-mail: eschung@skku.edu

Received 27 April 201231 July 2012       Accepted 24 November 2012

Copyright © 2007 Korean Ophthalmological Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To determine the correlations between donor endothelial lenticule thickness and visual prognosis in Descemet's stripping automated endothelial keratoplasty (DSAEK).

Methods

The present study included 22 patients (22 eyes), who underwent DSAEK surgery in our clinic due to endothelial decompensation. BCVA (log MAR) was compared at 1 month, 3 months and 6 months postoperatively between the thin lenticule group and thick lenticule group (≥130 μm).

Results

The BCVA (log MAR) at 1 month postoperatively was 0.46 ± 0.22 in the thin lenticule group, and 0.71 ± 0.26 in the thick lenticule group, and significant statistical correlations between donor lenticule thickness and visual acuity were observed (p = 0.025). However, no significant correlations were observed at 3 months (p = 0.129) and 6 months (p = 0.141) postoperatively.

Conclusions

The thin donor lenticule (<130 μm) can result in better visual acuity at 1 month postoperatively than the thick donor lenticule (≥130 μm), however, there is no difference in visual acuity between the 2 groups at 3 and 6 months postoperatively.

Keywords: DSAEK, DSAEK visual prognosis, Endothelial thickness, Lenticule

References

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Figure 1.
The comparison of visual prognosis after DSAEK surgery between thin lenticule group and thick lenticule group.
jkos-54-210f1.tif
Table 1.
Demographics for patients undergoing DSAEK
Thin lenticule (n = 11) Thick lenticule (n = 11)
Mean age ± standard deviation (years) 61 ± 10 64 ± 14
Sex (female(%)/male(%)) 2 (18)/9 (82) 2 (18)/9 (82)
Reason for transplantation (n (%))
Fuchs 3 (27) 2 (18)
PBK 7 (64) 8 (73)
Other endothelial dysfunction 1 (9) 1 (9)

PBK = pseudophakic bullous keratopathy.

Table 2.
Comparison of thickness and visual outcomes between two groups (thin lenticule vs thick lenticule)
Thickness (μm) Preoperative BCVA (log MAR) 1 month BCVA (log MAR) 3 months BCVA (log MAR) 6 months BCVA (log MAR)
Thin lenticule (n = 11) 110.5 ± 13.3 1.07 ± 0.50 0.46 ± 0.22 0.36 ± 0.17 0.27 ± 0.15
Thick lenticule (n = 11) 177.6 ± 19.3 1.31 ± 0.47 0.71 ± 0.26 0.54 ± 0.32 0.38 ± 0.18
p-value 0.005 0.249 0.025 0.129 0.141
Values are presented as mean ± SD.
BCVA = best corrected visual acuity.
Table 3.
Comparison of endothelial cell Count between two groups (thin lenticule vs thick lenticule)
Preoperative (number/mm2) 6 months (number/mm2)
Thin lenticule (n = 9) 2746 ± 236 2033 ± 614
Thick lenticule (n = 9) 2708 ± 395 1729 ± 509
p-value 0.790 0.270
Values are presented as mean ± SD.
Table 4.
Comparison of central corneal chickness measured by pachymetry between two groups (thin lenticule vs thick lenticule)
3 months (μm) 6 months (μm)
Thin lenticule (n = 8) 599 ± 93 616 ± 96
Thick lenticule (n = 10) 622 ± 63 627 ± 62
p-value 0.516 0.776

Values are presented as mean ± SD.

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